{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:18:37Z","timestamp":1792739917526,"version":"4.5.0"},"reference-count":17,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,1,1]]},"abstract":"<jats:p>Key parameters of the endocrine pancreas, such as islet number, islet mass, \u03b2-cell mass, and \u03b1-cell mass, were studied in different strains of inbred mice to investigate the impact of genetic background on the size and structure of the endocrine pancreas. Six mice from each of seven different strains of inbred mice were included in the study. For all parameters investigated, there was a pronounced interstrain variation. ANCOVA showed that only mouse strain was statistically significant as an explanatory parameter for the number of islets. Mouse strain, body weight, and pancreas mass reached statistical significance as explanatory parameters for the islet mass, with mouse strain as the most significant predictor. These data show that genetic background is the most important predictor of both the number of islets and total islet volume. We also conclude that inbred mice could be a valuable resource to identify the genes responsible for the size and structure of the endocrine pancreas.<\/jats:p>","DOI":"10.2337\/diabetes.54.1.133","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"133-137","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":80,"title":["Genetic Background Determines the Size and Structure of the Endocrine Pancreas"],"prefix":"10.2337","volume":"54","author":[{"given":"Troels","family":"Bock","sequence":"first","affiliation":[{"name":"Research Laboratory for Stereology and Neuroscience, Hovedstadens Sygehusf\u00e6llesskab Bispebjerg Hospital, Copenhagen University Hospi-tal, Copenhagen, Denmark"},{"name":"Hovedstadens Sygehusf\u00e6llesskab Bartholin Institute, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Pakkenberg","sequence":"additional","affiliation":[{"name":"Research Laboratory for Stereology and Neuroscience, Hovedstadens Sygehusf\u00e6llesskab Bispebjerg Hospital, Copenhagen University Hospi-tal, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Buschard","sequence":"additional","affiliation":[{"name":"Hovedstadens Sygehusf\u00e6llesskab Bartholin Institute, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031208584044300_R1","doi-asserted-by":"crossref","unstructured":"Like AA, Chick WL: Mitotic division in pancreatic beta cells. Science\u2008163:941\u2013943,1969","DOI":"10.1126\/science.163.3870.941"},{"key":"2022031208584044300_R2","doi-asserted-by":"crossref","unstructured":"Bonner-Weir S, Sharma A: Pancreatic stem cells. J Pathol\u2008197:519\u2013526,2002","DOI":"10.1002\/path.1158"},{"key":"2022031208584044300_R3","doi-asserted-by":"crossref","unstructured":"Rosenberg L: Induction of islet cell neogenesis in the adult pancreas: the partial duct obstruction model. Microsc Res Tech\u200843:337\u2013346,1998","DOI":"10.1002\/(SICI)1097-0029(19981115)43:4<337::AID-JEMT8>3.0.CO;2-U"},{"key":"2022031208584044300_R4","doi-asserted-by":"crossref","unstructured":"Guz Y, Nasir I, Teitelman G: Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology\u2008142:4956\u20134968,2001","DOI":"10.1210\/endo.142.11.8501"},{"key":"2022031208584044300_R5","doi-asserted-by":"crossref","unstructured":"Lipsett M, Finegood DT: \u03b2-Cell neogenesis during prolonged hyperglycemia in rats. Diabetes\u200851:1834\u20131841,2002","DOI":"10.2337\/diabetes.51.6.1834"},{"key":"2022031208584044300_R6","doi-asserted-by":"crossref","unstructured":"Skau M, Pakkenberg B, Buschard K, Bock T: Linear correlation between the total islet mass and the volume-weighted mean islet volume. Diabetes\u200850:1763\u20131770,2001","DOI":"10.2337\/diabetes.50.8.1763"},{"key":"2022031208584044300_R7","doi-asserted-by":"crossref","unstructured":"Bock T, Pakkenberg B, Buschard K: Increased islet volume but unchanged islet number in ob\/ob mice. Diabetes\u200852:1716\u20131722,2003","DOI":"10.2337\/diabetes.52.7.1716"},{"key":"2022031208584044300_R8","doi-asserted-by":"crossref","unstructured":"Dor Y, Brown J, Martinez OI, Melton DA: Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature\u2008429:41\u201346,2004","DOI":"10.1038\/nature02520"},{"key":"2022031208584044300_R9","doi-asserted-by":"crossref","unstructured":"Gundersen HJ, Jensen EB: The efficiency of systematic sampling in stereology and its prediction. J Microsc\u2008147 (Pt. 3):229\u2013263,1987","DOI":"10.1111\/j.1365-2818.1987.tb02837.x"},{"key":"2022031208584044300_R10","doi-asserted-by":"crossref","unstructured":"Bock T, Kyhnel A, Pakkenberg B, Buschard K: The postnatal growth of the beta-cell mass in pigs. J Endocrinol\u2008179:245\u2013252,2003","DOI":"10.1677\/joe.0.1790245"},{"key":"2022031208584044300_R11","doi-asserted-by":"crossref","unstructured":"Gundersen HJ: Stereology of arbitrary particles: a review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J Microsc\u2008143:3\u201345,1986","DOI":"10.1111\/j.1365-2818.1986.tb02764.x"},{"key":"2022031208584044300_R12","doi-asserted-by":"crossref","unstructured":"Singer JB, Hill AE, Burrage LC, Olszens KR, Song J, Justice M, O\u2019Brien WE, Conti DV, Witte JS, Lander ES, Nadeau JH: Genetic dissection of complex traits with chromosome substitution strains of mice. Science\u2008304:445\u2013448,2004","DOI":"10.1126\/science.1093139"},{"key":"2022031208584044300_R13","doi-asserted-by":"crossref","unstructured":"Swenne I, Andersson A: Effect of genetic background on the capacity for islet cell replication in mice. Diabetologia\u200827:464\u2013467,1984","DOI":"10.1007\/BF00273912"},{"key":"2022031208584044300_R14","doi-asserted-by":"crossref","unstructured":"Chua S Jr, Liu SM, Li Q, Yang L, Thassanapaff VT, Fisher P: Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB- Lepr (db)) and obese (DBA- Lep (ob)) mice. Diabetologia\u200845:976\u2013990,2002","DOI":"10.1007\/s00125-002-0880-z"},{"key":"2022031208584044300_R15","doi-asserted-by":"crossref","unstructured":"Kulkarni RN, Almind K, Goren HJ, Winnay JN, Ueki K, Okada T, Kahn CR: Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor\/insulin receptor substrate-1 double heterozygous mice. Diabetes\u200852:1528\u20131534,2003","DOI":"10.2337\/diabetes.52.6.1528"},{"key":"2022031208584044300_R16","doi-asserted-by":"crossref","unstructured":"Gonzalez C, Cuvellier S, Hue-Beauvais C, Levi-Strauss M: Genetic control of non obese diabetic mice susceptibility to high-dose streptozotocin-induced diabetes. Diabetologia\u200846:1291\u20131295,2003","DOI":"10.1007\/s00125-003-1168-7"},{"key":"2022031208584044300_R17","doi-asserted-by":"crossref","unstructured":"Goren HJ, Kulkarni RN, Kahn CR: Glucose homeostasis and tissue transcript content of insulin signalling intermediates in four inbred strains of mice: C57BL\/6, C57BLKS\/6, DBA\/2, and 129X1. Endocrinology\u2008145:3307\u20133323,2004","DOI":"10.1210\/en.2003-1400"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/54\/1\/133\/650614\/zdb00105000133.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/54\/1\/133\/650614\/zdb00105000133.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:23:41Z","timestamp":1667406221000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/54\/1\/133\/14646\/Genetic-Background-Determines-the-Size-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diabetes.54.1.133","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1,1]]}}}