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After infection, the induction of monocyte chemoattractant protein-1 (MCP-1) and KC mRNA in the liver of db\/db mice and the MCP-1 mRNA expression in the liver of ob\/ob mice was decreased compared with their heterozygote littermates. Leptin replacement in ob\/ob mice resulted in improvement of anti-listerial resistance and the MCP-1 mRNA expression. The elimination of L. monocytogenes was significantly enhanced, and the expression of MCP-1 and KC mRNA was completely reversed in db\/db mice by insulin treatment. These results suggest that leptin is required for host resistance to L. monocytogenes infection and that hyperglycemia caused by leptin deficiency is involved in the inefficient elimination of bacteria from the liver. Moreover, defect of MCP-1 expression in the liver may be involved in the attenuated host resistance in these mutant mice.<\/jats:p>","DOI":"10.2337\/diabetes.54.1.182","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"182-189","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":96,"title":["Impairment of Host Resistance to<i>Listeria monocytogenes<\/i>Infection in Liver of<i>db\/db<\/i>and<i>ob\/ob<\/i>Mice"],"prefix":"10.2337","volume":"54","author":[{"given":"Shin","family":"Ikejima","sequence":"first","affiliation":[{"name":"Third Department of Medicine, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan"},{"name":"Department of Bacteriology, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanae","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sashinami","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiji","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Hirosaki University School of Health Sciences, Hirosaki University, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Suda","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Nakane","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031208584919800_R1","doi-asserted-by":"crossref","unstructured":"Zhang Y, Proenca R, Maffel M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. 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