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AT2Ry\/\u2212 mice had a normal adiposity but displayed a striking adipose tissue phenotype characterized by small adipocytes and an increase in cell number. In muscle, the expression of several genes involved in lipid metabolism, including fatty acid translocase, uncoupling protein-3, peroxisome proliferator\u2013activated receptors (\u03b1, \u03b4), and carnitine palmitoyl transferase-1, was increased in AT2R-deficient mice. In response to high-fat feeding, these mice were protected against obesity and obesity-related glucose intolerance, as assessed by glucose tolerance tests. Moreover, lipid oxidation assessed by indirect calorimetry was higher in AT2R-deficient mice than in wild-type mice, irrespective of the diet. This suggests that AT2R-dependent signaling exerts a direct or indirect negative control on lipid utilization in muscles. These data support the idea that AT2R-dependent Ang II signaling increases adipose cell mass and glucose intolerance and thus could participate to the deleterious effects of a high-fat diet.<\/jats:p>","DOI":"10.2337\/diabetes.54.4.991","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"991-999","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":178,"title":["Deletion of the Angiotensin Type 2 Receptor (AT2<i>R<\/i>) Reduces Adipose Cell Size and Protects From Diet-Induced Obesity and Insulin Resistance"],"prefix":"10.2337","volume":"54","author":[{"given":"Laurent","family":"Yvan-Charvet","sequence":"first","affiliation":[{"name":"Unit 465, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Even","sequence":"additional","affiliation":[{"name":"UMR914, Institut National de la Recherche Agronomique, INAPG, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May","family":"Bloch-Faure","sequence":"additional","affiliation":[{"name":"Unit 367, INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miche\u0300le","family":"Guerre-Millo","sequence":"additional","affiliation":[{"name":"Unit 465, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Moustaid-Moussa","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Agricultural Experiment Station, University of Tennessee, Knoxville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Ferre","sequence":"additional","affiliation":[{"name":"Unit 465, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Quignard-Boulange","sequence":"additional","affiliation":[{"name":"Unit 465, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031209472852100_R1","doi-asserted-by":"crossref","unstructured":"Cassis LA, Saye JA, Peach MJ: Location and regulation of rat angiotensinogen messenger RNA. 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