{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:53:56Z","timestamp":1771628036817,"version":"3.50.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,1,1]]},"abstract":"<jats:p>Thirty-one children suffering from type I diabetes mellitus were arranged at onset of the disease in two different groups. Group 1 was treated with oral prednisone (60 mg \u00b7 m\u22122 \u00b7 day\u22121 for 14 days, 30 and 15 mg \u00b7 m\u22122 \u00b7 day\u22121 for 7 days). Group 2 matched the control group. All patients were treated with continuous subcutaneous insulin infusion for the first 15 days of treatment, and then with two daily injections of a mixture of intermediate- and fast-acting insulin. All subjects were followed for 1 yr. Group 1 required more insulin than group 2 after 30 days (1.5 \u00b1 0.3 vs. 0.6 + 0.2 U \u00b7 kg\u22121 \u00b7 day\u22121, P &amp;lt; .001) and after 60 days (0.8 \u00b1 0.1 vs. 0.5 \u00b1 0.06 U \u00b7 kg\u22121 \u00b7 day\u22121, P &amp;lt; .001). After 3 mo, both groups reached the lowest mean stable HbA1 level (8.4 \u00b1 0.4 and 8.3 \u00b1 0.4% group 1 and 2 respectively). Between the 2nd and 9th mo of follow-up, mean postbreakfast C-peptide concentration increased in both groups. The highest levels of fasting C-peptide were reached by group 1 after 90 days (0.77 \u00b1 0.32 nM) and group 2 after 60 days (0.34 \u00b1 0.09 nM). The largest partial remission (C-peptide 0.3 nM, insulin requirement &amp;lt;0.5 U \u00b7 kg\u22121 \u00b7 day\u22121 and no glycosuria) was observed in group 1 after 180 days (5 of 16 patients) and in group 2 after 60 days (5 of 15 patients). We found no significant difference between the two groups in fasting and postbreakfast C-peptide levels, stable HbA1, and remission during 1-yr follow-up. Short-term prednisone therapy in newly diagnosed type I diabetic children does not considerably modify the natural history of the disease during the 1st yr.<\/jats:p>","DOI":"10.2337\/diacare.10.1.39","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"39-43","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":12,"title":["Prednisone Treatment in Newly Diagnosed Type I Diabetic Children: 1-Yr Follow-Up"],"prefix":"10.2337","volume":"10","author":[{"given":"Laila","family":"Mistura","sequence":"first","affiliation":[{"name":"Scientific Institute S. Raffaele, Department of Pediatrics, Endocrine Unit, University of Milan\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Beccaria","sequence":"additional","affiliation":[{"name":"Scientific Institute S. Raffaele, Department of Pediatrics, Endocrine Unit, University of Milan\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Meschi","sequence":"additional","affiliation":[{"name":"Scientific Institute S. Raffaele, Department of Pediatrics, Endocrine Unit, University of Milan\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Flores","family":"D'arcais,","sequence":"additional","affiliation":[{"name":"Scientific Institute S. Raffaele, Department of Pediatrics, Endocrine Unit, University of Milan\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Pellini","sequence":"additional","affiliation":[{"name":"Scientific Institute S. Raffaele, Department of Pediatrics, Endocrine Unit, University of Milan\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Puzzovio","sequence":"additional","affiliation":[{"name":"Scientific Institute S. Raffaele, Department of Pediatrics, Endocrine Unit, University of Milan\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Chiumello","sequence":"additional","affiliation":[{"name":"Scientific Institute S. Raffaele, Department of Pediatrics, Endocrine Unit, University of Milan\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/10\/1\/39\/438226\/10-1-39.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/10\/1\/39\/438226\/10-1-39.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T23:11:08Z","timestamp":1647040268000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/10\/1\/39\/766\/Prednisone-Treatment-in-Newly-Diagnosed-Type-I"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.10.1.39","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1,1]]}}}