{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:18:27Z","timestamp":1758824307447},"reference-count":0,"publisher":"American Diabetes Association","issue":"3","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,5,1]]},"abstract":"<jats:p>Studies of fat cells from patients with newly diagnosed, untreated non-insulin-dependent diabetes mellitus (NIDDM) have revealed severe abnormalities in insulin action on glucose transport and metabolism. To determine whether these defects can be reversed if good glycemic control is reached by dietary treatment, eight moderately obese NIDDM subjects were studied at diagnosis and again when the patients had been in good glycemic control induced by low-energy dieting for at least 2 mo (absence of glycosuria and fasting plasma glucose &amp;lt;7 mM). Average body weight decreased by 8 kg (P &amp;lt; .05). Fasting plasma glucose decreased from 11.5 \u00b1 1.2 to 6.9 \u00b1 0.9 mM, whereas fasting serum insulin concentrations were unchanged. Adipocyte insulin binding at tracer concentration (15 pM, 37\u00b0C) was not changed significantly (1.94 \u00b1 0.52 to 2.05 \u00b1 0.62% per 30 cm2 surface area\/ml). The basal (noninsulin-stimulated) glucose transport (tracer glucose concentration 5 \u03bcM) increased from 25 \u00b1 12 to 44 \u00b1 14 pmol \u00b7 90 min\u22121 \u00b7 10 cm\u22122 surface area (P &amp;lt; .02). The maximally insulin-stimulated glucose transport rate increased from 35 \u00b1 20 to 78 \u00b1 26 pmol\/90 min (P &amp;lt; .01). The percentage insulin response above basal levels increased from 31 \u00b1 40 to 89 \u00b1 58% (P &amp;lt; .01). The insulin sensitivity (half-maximally stimulating insulin concentrations) was also improved (P &amp;lt; .05). Glucose conversion rates to total lipids increased 34 \u00b1 62 and 65 \u00b1 80% in basal cells and maximally insulin-stimulated cells, respectively (.2 &amp;gt; P &amp;gt; .1 , .1 &amp;gt; P &amp;gt; .05). The percentage insulin response above basal level increased from 30 \u00b1 24 to 67 \u00b1 52% (P &amp;lt; .05). The percentage insulin response above basal level of glucose conversion to CO2 also increased (P &amp;lt; .05). The results after diet treatment were not different from those of normal controls. We conclude that dietary treatment of moderately obese NIDDM patients that leads to good glycemic control results in reversal of the abnormalities observed in adipocytes of untreated NIDDM subjects.<\/jats:p>","DOI":"10.2337\/diacare.10.3.306","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"306-312","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":7,"title":["Adipocyte Insulin Binding and Action in Moderately Obese NIDDM Patients After Dietary Control of Plasma Glucose: Reversal of Postbinding Abnormalities"],"prefix":"10.2337","volume":"10","author":[{"given":"Elisabeth","family":"Hj\u00d8llund","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Departments of Internal Medicine and Clinical Chemistry, Aarhus Hospital\u2008Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluf","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Departments of Internal Medicine and Clinical Chemistry, Aarhus Hospital\u2008Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels Schwartz","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Departments of Internal Medicine and Clinical Chemistry, Aarhus Hospital\u2008Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/10\/3\/306\/514263\/10-3-306.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/10\/3\/306\/514263\/10-3-306.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T23:14:12Z","timestamp":1647040452000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/10\/3\/306\/853\/Adipocyte-Insulin-Binding-and-Action-in-Moderately"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,5,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.10.3.306","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,5,1]]}}}