{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:55:48Z","timestamp":1791410148559,"version":"4.3.3"},"reference-count":0,"publisher":"American Diabetes Association","issue":"2","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,2,1]]},"abstract":"<jats:p>A 64-yr-old man with benign monoclonal gammopathy developed recurrent episodes of severe hypoglycemia but lacked evidence of insulinoma or exogenous insulin administration. The patient's plasma was found to contain anti-insulin antibodies and large amounts of extractable insulin (1110 \u03bcU\/ml), which was identified as human insulin by high-performance liquid chromatography (HPLC). The anti-insulin antibodies consisted solely of IgG and A-light chains. Scatchard analysis of these antibodies revealed an almost straightline relationship, with markedly low affinity and high capacity. An immune complex made of 125l-labeled insulin and the patient's antibodies emerged in a molecular-sieve HPLC as almost a single peak, suggesting a homogeneous antibody population. In addition, the patient's M protein was separately shownto be the IgG and \u03bb\u2013light-chain type. We suggest that the insulin autoantibodies responsible for the spontaneous hypoglycemia in this patient are monoclonal and of M protein origin.<\/jats:p>","DOI":"10.2337\/diacare.12.2.147","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"147-150","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":35,"title":["Insulin Autoimmune Syndrome Associated With Benign Monoclonal Gammopathy: Evidence for Monoclonal Insulin Autoantibodies"],"prefix":"10.2337","volume":"12","author":[{"given":"Taro","family":"Wasada","sequence":"first","affiliation":[{"name":"Diabetes Center, Tokyo Women's Medical College\u2008Tokyo\u2008City of Kushiro Hospital\u2008Kushiro, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Diabetes Center, Tokyo Women's Medical College\u2008Tokyo\u2008City of Kushiro Hospital\u2008Kushiro, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumiko","family":"Takayama","sequence":"additional","affiliation":[{"name":"Diabetes Center, Tokyo Women's Medical College\u2008Tokyo\u2008City of Kushiro Hospital\u2008Kushiro, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshi","family":"Yao","sequence":"additional","affiliation":[{"name":"Diabetes Center, Tokyo Women's Medical College\u2008Tokyo\u2008City of Kushiro Hospital\u2008Kushiro, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukimasa","family":"Hirata","sequence":"additional","affiliation":[{"name":"Diabetes Center, Tokyo Women's Medical College\u2008Tokyo\u2008City of Kushiro Hospital\u2008Kushiro, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadao","family":"Ishii","sequence":"additional","affiliation":[{"name":"Diabetes Center, Tokyo Women's Medical College\u2008Tokyo\u2008City of Kushiro Hospital\u2008Kushiro, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/12\/2\/147\/662901\/12-2-147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/12\/2\/147\/662901\/12-2-147.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T00:50:00Z","timestamp":1647046200000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/12\/2\/147\/2169\/Insulin-Autoimmune-Syndrome-Associated-With-Benign"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,2,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.12.2.147","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,2,1]]}}}