{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:16:34Z","timestamp":1761822994065},"reference-count":0,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,1,1]]},"abstract":"<jats:p>Objective\u2014 To evaluate the frequency and correlates of glomerular hyperfiltration in NIDDM patients without overt proteinuria.<\/jats:p>\n               <jats:p>Research Design and Methods\u2014 A cross-sectional study was conducted. Seventy-one consecutive NIDDM patients attending an outpatient clinic, with Albustix-tested negative urine and a 24-h AER &amp;lt;200 \u03bcgrams\/min, were examined for long-term complications of diabetes. We measured their GFR (51Cr-EDTA single-injection method), 24-h AER (RIA), plasma creatinine, HbA1c, total cholesterol, triglycerides, urinary glucose, and urea.<\/jats:p>\n               <jats:p>Results\u2014 GFR above the upper limit of the normal range for age-matched control subjects (137.1 ml\u00b7min\u22121 \u00b7 1.73 m2) was present in 15 of 71 (21%) NIDDM patients. Subjects with normal and hyperfiltration did not differ in terms of age, sex distribution, BMI, duration of NIDDM, BP, AER, or frequency of long-term complications. Plasma glucose was significantly higher in subjects with hyperfiltration (mean [range]: 12.8 [4.3\u201318.7] vs. 8.7 [2.6\u201317.5] mM). HbA1c failed to reach statistical significance, although it tended to be higher in the group with hyperfiltration (10.4 [6.7\u201313.9] vs. 9.4 [4.2\u201316.5]%, P = 0.10). Age (rS \u22120.37, P = 0.002), FPG (rS 0.45, P &amp;lt; 0.0005), total cholesterol (rS \u22120.31, P = 0.008), and glycosuria (rS 0.40, P = 0.001) correlated significantly with GFR. In a stepwise multiple regression analysis, FPG, age, and total cholesterol emerged as significant correlates of the dependent variable GFR.<\/jats:p>\n               <jats:p>Conclusions\u2014 Hyperfiltration occurred in 21% of NIDDM patients without overt proteinuria. FPG and age significant correlates of the GFR in these patients. Cholesterol is significantly (although only modestly) correlated with the GFR.<\/jats:p>","DOI":"10.2337\/diacare.16.1.115","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"115-119","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":31,"title":["Glomerular Hyperfiltration in NIDDM Patients Without Overt Proteinuria"],"prefix":"10.2337","volume":"16","author":[{"given":"Sandra P","family":"Silveiro","sequence":"first","affiliation":[{"name":"Endocrine Unit, Hospital de Cl\u00ednicas de Porto Alegre, Federal University of Rio Grande do Sul\u2008Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio","family":"Friedman","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Hospital de Cl\u00ednicas de Porto Alegre, Federal University of Rio Grande do Sul\u2008Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge L","family":"Gross","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Hospital de Cl\u00ednicas de Porto Alegre, Federal University of Rio Grande do Sul\u2008Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/16\/1\/115\/444547\/16-1-115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/16\/1\/115\/444547\/16-1-115.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T13:27:33Z","timestamp":1647091653000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/16\/1\/115\/20729\/Glomerular-Hyperfiltration-in-NIDDM-Patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.16.1.115","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1,1]]}}}