{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:08:09Z","timestamp":1761894489756},"reference-count":0,"publisher":"American Diabetes Association","issue":"11","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To determine the 10 -yr incidence of impaired glucose tolerance and NIDDM in families with a clustering of endogenous hypertriglyceridemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>The prospective population study, where the oral glucose tolerance test and the measurement of serum lipids and lipoproteins were performed at the baseline examination and after the 10-yr followup, was conducted on 56 subjects (17\u201360 yr of age at the baseline). The subjects were from six pedigrees with a clustering of endogenous hypertriglyceridemia, and 47 of these subjects attended the follow-up 10 yr later.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>In the study families, the prevalence of glucose intolerance and NIDDM increased from 15 to 49% (P &amp;lt; 0.001) and from 2 to 21% (P &amp;lt; 0.001), respectively, over the 10-yr period. When grouped according to the baseline serum triglyceride tertiles, 76% (P &amp;lt; 0.01) of the family members with highest serum triglycerides were glucose intolerant (29% impaired glucose tolerance, 47% NIDDM) at follow-up compared with 20% of those with lowest serum triglycerides. In discriminant analysis, including age, body mass index, treatment with thiazides and \u03b2-blocking agents, and 2-h serum insulin concentration, the baseline serum triglycerides still remained as an independent predictor of development of impaired glucose tolerance and NIDDM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Families with a clustering of hypertriglyceridemia are at increased risk of NIDDM, and in these families elevation of serum triglycerides serves as a risk marker of glucose intolerance and NIDDM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/diacare.16.11.1494","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"1494-1501","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":20,"title":["Does Familial Hypertriglyceridemia Predispose to NIDDM?"],"prefix":"10.2337","volume":"16","author":[{"given":"Timo","family":"Sane","sequence":"first","affiliation":[{"name":"Department of Medicine, Helsinki University Central Hospital\u2008Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marja-Riitta","family":"Taskinen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Helsinki University Central Hospital\u2008Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/16\/11\/1494\/441942\/16-11-1494.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/16\/11\/1494\/441942\/16-11-1494.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T11:58:01Z","timestamp":1647086281000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/16\/11\/1494\/17275\/Does-Familial-Hypertriglyceridemia-Predispose-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1993,11,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.16.11.1494","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,11,1]]}}}