{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:59:30Z","timestamp":1761512370170},"reference-count":0,"publisher":"American Diabetes Association","issue":"4","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with benfluorex or placebo for 2 wk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>The study had a double-blind, cross-over design. Insulin sensitivity was measured with the euglycemic hyperinsulinemic glucose clamp technique at two different insulin infusion rates: 0.05 (clamp 1) and 0.10 U.kg\u22121 \u00b7 h\u22121 (clamp 2).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Subanalysis of the glucose infusion rate under steady-state conditions in the last 30 min of clamp 2 yielded a glucose infusion rate of 5.36 and 3.87 mmol.kg\u22121.min\u22121 after benfluorex and placebo, respectively (P = 0.018).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Benfluorex increases insulin sensitivity in obese type II diabetic patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/diacare.16.4.557","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"557-559","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":14,"title":["Effects of Benfluorex on Insulin Resistance and Lipid Metabolism in Obese Type II Diabetic Patients"],"prefix":"10.2337","volume":"16","author":[{"given":"Rutgert","family":"Bianchi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University Hospital\u2008Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian","family":"Bongers","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital\u2008Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"Bravenboer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital\u2008Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D Willem","family":"Erkelens","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital\u2008Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/16\/4\/557\/643099\/16-4-557.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/16\/4\/557\/643099\/16-4-557.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T13:39:29Z","timestamp":1647092369000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/16\/4\/557\/20041\/Effects-of-Benfluorex-on-Insulin-Resistance-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,4,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.16.4.557","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,4,1]]}}}