{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T18:18:48Z","timestamp":1694629128353},"reference-count":0,"publisher":"American Diabetes Association","issue":"7","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,7,1]]},"abstract":"<jats:p>Objective\u2014 To determine if knowledge of characteristics of insulin response to various secretagogues during the preclinical phase of type I diabetes may facilitate the diagnosis of subjects at risk.<\/jats:p>\n               <jats:p>Research Design and Methods\u2014 A test consisting of sequential intravenous challenge with glucose (0.3 g\/kg) and glucagon (1 mg, 10 min after the end of glucose injection) was performed on 171 ICA\u2212 relatives of type I diabetic patients, 18 ICA+ relatives of type I diabetic patients, and 5 transiently hyperglycemic subjects. Acute response to glucose was expressed as the sum of plasma insulin at 2 and 5 min and response to glucagon as the increase in plasma insulin after 10 min.<\/jats:p>\n               <jats:p>Results\u2014 Responses below the lower 95% confidence interval in the ICA\u2212 population (40 and 43 \u03bcU\/ml for glucose and glucagon, respectively) were considered abnormal. The two values were correlated (r = 0.62). Abnormalities coexisted in 2.3% of the ICA\u2212 group, 11% of the ICA+ group, and 100% of the transiently hyperglycemic group. All the relatives who subsequently developed diabetes or hyperglycemic subjects who required insulin exhibited combined abnormalities. Some ICA\u2212 and ICA+ relatives were tested repeatedly over a follow-up period of 1.5\u20134 yr. Although the intraindividual coefficient of variation for the two responses was high (28 and 30%), values tended to run parallel in both ICA+ and ICA\u2212 relatives. In 2 patients monitored for 2 and 4 yr before diabetes developed, both responses declined at the same rate. In terms of prediction of diabetes, sensitivity of combined abnormalities was high (100%). But compared with the intravenous glucose tolerance test, improvement of specificity by the double challenge was not statistically significant.<\/jats:p>\n               <jats:p>Conclusions\u2014 Both insulin responses to glucose and glucagon are related. They depend on the secretory capacity of \u03b2-cells and simultaneously become abnormal in the prediabetic phase.<\/jats:p>","DOI":"10.2337\/diacare.16.7.973","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"973-977","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":4,"title":["Acute Insulin Response to Glucose and Glucagon in Subjects at Risk of Developing Type I Diabetes"],"prefix":"10.2337","volume":"16","author":[{"given":"Bernard","family":"Vialettes","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Nutrition, Laboratory of Diabetology, University of Marseille\u2008Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Zevaco-Mattei","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nutrition, Laboratory of Diabetology, University of Marseille\u2008Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Thirion","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nutrition, Laboratory of Diabetology, University of Marseille\u2008Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Lassmann-Vague","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nutrition, Laboratory of Diabetology, University of Marseille\u2008Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"Pieron","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nutrition, Laboratory of Diabetology, University of Marseille\u2008Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Mercier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nutrition, Laboratory of Diabetology, University of Marseille\u2008Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Vague","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nutrition, Laboratory of Diabetology, University of Marseille\u2008Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/16\/7\/973\/442179\/16-7-973.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/16\/7\/973\/442179\/16-7-973.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T12:55:42Z","timestamp":1647089742000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/16\/7\/973\/18378\/Acute-Insulin-Response-to-Glucose-and-Glucagon-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1993,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.16.7.973","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7,1]]}}}