{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:28Z","timestamp":1761058648198},"reference-count":0,"publisher":"American Diabetes Association","issue":"4","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To assess the influence of autonomic neuropathy on toe blood pressure (TBP), a parameter used currently as an ischemic index.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>The age-matched study subjects included 20 non-insulin-dependent diabetes mellitus (NIDDM) patients with autonomic neuropathy (DN) and 10 NIDDM patients without autonomic neuropathy (D), assessedby standard cardiovascular tests and galvanic skin response, and 8 control subjects (C). None of the subjects had peripheral vascular disease (PVD) (ankle\/brachial index 0.9\u20131.1.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The TBP and toe\/brachial index (TBI) were significantly lower in DN than in C and D (P &amp;lt; 0.01). The saturation index (SI), the ratiobetween foot venous and arterial partial pressure of oxygen (PO2), was significantly higher in DN than in C and D (P &amp;lt; 0.05). An inverse relationship was found between TBI and SI (r = 0.554, P = 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The autonomic nervous system directly influences peripheral circulation. In diabetic patients without PVD, a failure of sympathetic fibers caused by autonomic neuropathy could lead to a reduction of TBP. Therefore, TBP cannot be used as an ischemic index in diabetic patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/diacare.17.4.284","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"284-287","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":23,"title":["Autonomic Neuropathy Influences Great Toe Blood Pressure"],"prefix":"10.2337","volume":"17","author":[{"given":"Luigi","family":"Uccioli","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Catholic University of Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Monticone","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Catholic University of Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Durola","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Catholic University of Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Russo","sequence":"additional","affiliation":[{"name":"Internal Medicine, Department of Surgery, Catholic University of Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaminio","family":"Mormile","sequence":"additional","affiliation":[{"name":"University of Rome \u201cTor Vergata\u201d; and the Departments of Internal Medicine, Catholic University of Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gioacchino","family":"Mennuni","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Catholic University of Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Menzinger","sequence":"additional","affiliation":[{"name":"Neurology, Catholic University of Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/17\/4\/284\/645103\/17-4-284.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/17\/4\/284\/645103\/17-4-284.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T12:10:19Z","timestamp":1647087019000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/17\/4\/284\/18816\/Autonomic-Neuropathy-Influences-Great-Toe-Blood"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,4,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.17.4.284","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4,1]]}}}