{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:47:27Z","timestamp":1761518847945},"reference-count":0,"publisher":"American Diabetes Association","issue":"5","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,5,1]]},"abstract":"\n OBJECTIVE<\/jats:title>\n To determine whether long-term treatment with an angiotensinconverting enzyme (ACE) inhibitor has a beneficial effect on the urinary microalbumin excretion and renal function in non-insulin-dependent diabetes mellitus (NIDDM) patients, enalapril (5 mg\/day) was administered for 48 months.<\/jats:p>\n <\/jats:sec>\n \n RESEARCH DESIGN AND METHODS<\/jats:title>\n Fifty-two patients with NIDDM who had persistent microalbuminuria in the range of 20\u2013300 mg\/24 h, serum creatinine &lt; 106.1 \u03bcM 1.2 mg\/dl), supine systolic blood pressure (BP) &lt;150 mmHg, supine diastolic BP &lt;90 mmHg, and HbA1c &lt;10% were divided into four groups. Twenty-six patients with normotension were divided at random into two groups; one group received enalapril (5 mg\/day) (NE group), the other did not receive enalapril (NC group). In the same way, 26 other patients who were already well-controlled with nifedipine (30 mg\/day) over a long-term period (4\u20136 years) were divided at random into two groups; one received enalapril (5 mg\/day) (HE group), the other did not receive enalapril (HC group).<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n After 48 months, urinary albumin excretion (UAE) was markedly reduced in group NE from 102.4 \u00d7\/\u00f7 1.3 to 55.5 \u00d7\/\u00f7 1.3 mg\/24 h (P &lt; 0.005), whereas no significant change occurred in group NC. In the well-controlled hypertensive groups, a significant reduction in UAE occurred in group HE (P &lt; 0.05), whereas no significant change occurred in group HC. No changes in creatinine clearance, BP, or blood glucose control were seen during the study.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Treatment with enalapril for 48 months may have a beneficial effect on the decline of microalbumin excretion in NIDDM patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/diacare.17.5.420","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"420-424","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":88,"title":["Effects of Long-Term Enalapril Treatment on Persistent Microalbuminuria in Well-Controlled Hypertensive and Normotensive NIDDM Patients"],"prefix":"10.2337","volume":"17","author":[{"given":"Takahisa","family":"Sano","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Matsumae","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromitsu","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Chubu-Rosai Hospital and the Third Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiro","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Hara","sequence":"additional","affiliation":[{"name":"Chubu-Rosai Hospital and the Third Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Chubu-Rosai Hospital and the Third Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigishi","family":"Hotta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nagoya University School of Medicine\u2008Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/17\/5\/420\/515817\/17-5-420.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/17\/5\/420\/515817\/17-5-420.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T12:00:04Z","timestamp":1647086404000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/17\/5\/420\/18116\/Effects-of-Long-Term-Enalapril-Treatment-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1994,5,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.17.5.420","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,5,1]]}}}