{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:09:51Z","timestamp":1758924591989},"reference-count":0,"publisher":"American Diabetes Association","issue":"7","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,7,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Pancreatic \u03b2-cell mass increases rapidly during gestation and early infancy. Infants who are small for gestational age, which is a marker for poor intrauterine nutrition, have reduced \u03b2-cell mass. We examined whether weight and length in early infancy, and in inference \u03b2-cell mass, is related to age at onset of insulindependent diabetes mellitus (IDDM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Data from infant records of 232 patients with IDDM, including birth weight, birth length, gestational age, weight at 6 months of age, and feeding history during the first 6 months of life, were analyzed. Maternal recall was not used for data collection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Low-birth-weight infants (&amp;lt;2.5 kg) showed a significantly earlier onset of diabetes (4.3 [3.2\u20136.0] years vs. 9.0 [5.3\u201311.8] years, median [25\u201375th percentile]; P &amp;lt; 0.0001). Infants small for gestational age also had earlier onset than those with birth weight above the 10th percentile after correction for gestational age (6.2 [3.6\u201310.5] vs. 9.2 [5.4\u201311.8] years; P &amp;lt; 0.0001). Infants with corrected birth weight: length ratio below the 10th percentile had earlier onset, as did infants with corrected 6-months weight below the 10th percentile (4.9 [2.8\u20136.0] years vs. 8.8 [5.2\u201311.8] years; P &amp;lt; 0.0001). Infants who were exclusively breast-fed for 6 months showed a slightly later onset of diabetes than those who were bottle- or mixed-fed, independent of weight (9.4 [5.0\u201311.3] years vs. 8.3 [4.2\u201311.7] years; P &amp;lt; 0.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Weight and growth parameters in utero and early infancy may influence the age at onset of IDDM. \u03b2-cell mass is likely to be a significant factor.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/diacare.17.7.653","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"653-656","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":16,"title":["Low-Birth-Weight Infants Show Earlier Onset of IDDM"],"prefix":"10.2337","volume":"17","author":[{"given":"Naznin","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes, Adelaide Children's Hospital\u2008South Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer J","family":"Couper","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Adelaide Children's Hospital\u2008South Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/17\/7\/653\/443969\/17-7-653.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/17\/7\/653\/443969\/17-7-653.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T12:51:30Z","timestamp":1647089490000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/17\/7\/653\/18280\/Low-Birth-Weight-Infants-Show-Earlier-Onset-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1994,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.17.7.653","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7,1]]}}}