{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T09:39:13Z","timestamp":1770543553550,"version":"3.49.0"},"reference-count":0,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1995,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To assess the prevalence, presentation, and risk factors of pentami-dine-induced dysglycernia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Blood glucose values were screened in 244 consecutive immunocompromised patients with Pneumocystis carinii pneumonia: 116 being treated with cotrimoxazole and 128 others with pentamidine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Two cotrimoxazole patients developed diabetes as a result of necrotiz-ing pancreatitis (1.7%); the others remained euglycemic. Forty-eight pentamidine-treated patients (38.5%) developed severe glucose homeostasis disorders: hypoglyce-mia in 7, hypoglycemia and then diabetes in 18, and diabetes alone in 23 (P &amp;lt; 0.001 vs. the cotrimoxazole group). Hypoglycemia was early, sudden, often recurrent, and life-threatening, associated with inappropriately high insulin levels in plasma; the B-cell response to stimuli was poor. Of the 41 diabetic patients, 26 required insulin therapy; their plasma C-peptide levels were lower than normal, and the B-cell secretory responses to stimuli were poor. Islet cell antibodies, insulin antibodies, and insulitis were not detected. The pentamidine-treated dysglycemic patients differed from their euglycemic counterparts by higher pentamidine doses (P &amp;lt; 0.001), higher plasma creatinine levels (P &amp;lt; 0.001), and more severe anoxia (P &amp;lt; 0.05) and shock (P &amp;lt; 0.001). Most of them had received pentamidine mesylate parenterally (n = 36; 75%); six others received the isethionate salt and six exclusively pentamidine aerosols.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Pentamidine-induced dysglycemic accidents are primarily due to inappropriate insulin release and toxicity to the islet B-cells. Drug accumulation due to excessive doses, iterative courses, and\/or renal impairment is the determining risk factor.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/diacare.18.1.47","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"47-55","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":68,"title":["Pentamidine-Induced Derangements of Glucose Homeostasis: Determinant roles of renal failure and drug accumulation: A study of 128 patients"],"prefix":"10.2337","volume":"18","author":[{"given":"Roger","family":"Assan","sequence":"first","affiliation":[{"name":"Service de Diabetologie, H\u00f4pital Bichat\u2008Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Perronne","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses, H\u00f4pital Claude Bernard\u2008Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Assan","sequence":"additional","affiliation":[{"name":"Service de Diabetologie, H\u00f4pital Bichat\u2008Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Chotard","sequence":"additional","affiliation":[{"name":"Service de Diabetologie, H\u00f4pital Bichat\u2008Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Mayaud","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, H\u00f4pital Tenon\u2008Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Matheron","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses, H\u00f4pital Claude Bernard\u2008Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Zucman","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital de Bic\u00eatre, Kremlin-Bice:tre\u2008Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/18\/1\/47\/443636\/18-1-47.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/18\/1\/47\/443636\/18-1-47.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T12:21:04Z","timestamp":1647087664000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/18\/1\/47\/19270\/Pentamidine-Induced-Derangements-of-Glucose"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.18.1.47","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1,1]]}}}