{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:40:57Z","timestamp":1789756857547,"version":"4.0.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"12","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1995,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To determine the association between exercise-induced albuminuria and the development of microalbuminuria over 10 years in subjects with insulin-dependent diabetes mellitus (IDDM) who were initially normoalbuminuric.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Thirty-two patients with IDDM and a resting urinary albumin\/creatinine ratio (UA\/UC) &amp;lt;2.1 mg\/mmol (&amp;lt; 15 \u03bcg\/min) were exercised after water loading on a treadmill for 20 min at double their resting heart rate. UA\/UC was determined before and after exercise. The exercise test was considered positive if the UA\/UC was &amp;gt;4.3 mg\/mmol (&amp;gt;30 \u03bcg\/min). Results were compared with resting UA\/UC after a 10-year follow-up. Persistent microalbuminuria was defined as a UA\/UC &amp;gt;2.1 mg\/mmol (&amp;gt; 15 \u03bcg\/min) in each of two early-morning urine collections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Five patients developed persistent microalbuminuria after 10 years, and four patients were predicted by a positive exercise test. Two patients with positive exercise tests did not develop persistent microalbuminuria. The sensitivity of the exercise test for the development of microalbuminuria was 80% (95% confidence interval [CI] 65.8\u201394.2%) and the specificity was 92.9% (95% CI 83.9\u2013100%). The postexercise UA\/UC was positively associated with the UA\/UC after 10 years (P = 0.005, R2 = 0.31). This association was independent of HbA1, systolic blood pressure, body mass index, and duration of diabetes, but HbA1 remained an independent predictor (P = 0.02) of UA\/UC at follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Exercise testing may be useful for identifying normoalbuminuric IDDM patients who are susceptible to the later development of microalbuminuria.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/diacare.18.12.1602","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"1602-1605","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":14,"title":["Exercise Testing as a Long-Term Predictor of the Development of Microalbuminuria in Normoalbuminuric IDDM Patients"],"prefix":"10.2337","volume":"18","author":[{"given":"Sheila F","family":"O'Brien","sequence":"first","affiliation":[{"name":"University Department of Medicine, The University of Western Australia, Royal Perth Hospital\u2008Perth, Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald F","family":"Watts","sequence":"additional","affiliation":[{"name":"University Department of Medicine, The University of Western Australia, Royal Perth Hospital\u2008Perth, Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake K","family":"Powrie","sequence":"additional","affiliation":[{"name":"Division of Medicine, United Medical and Dental Schools of Guy's and St. Thomas's Hospitals\u2008St. Thomas Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Alexandra Hospital\u2008Portsmouth, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/18\/12\/1602\/443131\/18-12-1602.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/18\/12\/1602\/443131\/18-12-1602.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T12:05:26Z","timestamp":1647086726000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/18\/12\/1602\/18703\/Exercise-Testing-as-a-Long-Term-Predictor-of-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1995,12,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.18.12.1602","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,12,1]]}}}