{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:29:31Z","timestamp":1778650171173,"version":"3.51.4"},"reference-count":0,"publisher":"American Diabetes Association","issue":"8","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1995,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To determine whether lipoic acid (LA) will reduce oxidative stress in diabetic peripheral nerves and improve neuropathy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>We used the model of streptozotocin-induced diabetic neuropathy (SDN) and evaluated the efficacy of LA supplementation in improving nerve blood flow (NBF), electrophysiology, and indexes of oxidative stress in peripheral nerves affected by SDN, at 1 month after onset of diabetes and in age-matched control rats. LA, in doses of 20, 50, and 100 mg\/kg, was administered intraperitoneally five times per week after onset of diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>NBF in SDN was reduced by 50% LA did not affect the NBF of normal nerves but improved that of SDN in a dose-dependent manner. After 1 month of treatment, LA-supplemented rats (100 mg\/kg) exhibited normal NBF. The most sensitive and reliable indicator of oxidative stress was reduction in reduced glutathione, which was significantly reduced in streptozotocin-induced diabetic and alpha-tocopherol-deficient nerves; it was improved in a dose-dependent manner in LA-supplemented rats. The conduction velocity of the digital nerve was reduced in SDN and was significantly improved by LA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>These studies suggest that LA improves SDN, in significant part by reducing the effects of oxidative stress. The drug may have potential in the treatment of human diabetic neuropathy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/diacare.18.8.1160","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"1160-1167","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":290,"title":["Lipoic Acid Improves Nerve Blood Flow, Reduces Oxidative Stress, and Improves Distal Nerve Conduction in Experimental Diabetic Neuropathy"],"prefix":"10.2337","volume":"18","author":[{"given":"Masaaki","family":"Nagamatsu","sequence":"first","affiliation":[{"name":"Neurophysiology Laboratory, Department of Neurology\u2008Mayo Foundation, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim K","family":"Nickander","sequence":"additional","affiliation":[{"name":"Neurophysiology Laboratory, Department of Neurology\u2008Mayo Foundation, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D","family":"Schmelzer","sequence":"additional","affiliation":[{"name":"Neurophysiology Laboratory, Department of Neurology\u2008Mayo Foundation, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Raya","sequence":"additional","affiliation":[{"name":"Experimental Toxicology and Neurotoxicology Unit, Department of Physiology, School of Medicine and Dentistry, University of Valencia\u2008Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra A","family":"Wittrock","sequence":"additional","affiliation":[{"name":"Neurophysiology Laboratory, Department of Neurology\u2008Mayo Foundation, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Tritschler","sequence":"additional","affiliation":[{"name":"ASTA Medica\u2008Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip A","family":"Low","sequence":"additional","affiliation":[{"name":"Neurophysiology Laboratory, Department of Neurology\u2008Mayo Foundation, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/18\/8\/1160\/443761\/18-8-1160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/18\/8\/1160\/443761\/18-8-1160.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T12:40:00Z","timestamp":1647088800000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/18\/8\/1160\/18972\/Lipoic-Acid-Improves-Nerve-Blood-Flow-Reduces"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,8,1]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1995,8,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.18.8.1160","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,8,1]]}}}