{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:46:29Z","timestamp":1759340789807},"reference-count":0,"publisher":"American Diabetes Association","issue":"7","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,7,1]]},"abstract":"\n OBJECTIVE<\/jats:title>\n To investigate the basis of central nervous system dysfunction in diabetes associated with the 3243 mitochondrial tRNA mutation, we studied neuroimaging findings in patients with this disease.<\/jats:p>\n <\/jats:sec>\n \n RESEARCH DESIGN AND METHODS<\/jats:title>\n We screened 205 diabetic patients. Those patients who had the 3243 mutation in leukocytes or muscle were enrolled. All the subjects underwent computed tomography (CT), magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), and N-isopropyl-p-[123I]iodoamphetamine ([123I]IMP) single-photon emission computed tomography (SPECT) of the brain.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n None of the nine subjects with the 3243 mutation had the typical clinical picture of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, and none had neurological focal signs. CT or MRI revealed diffuse brain atrophy in three patients (33%) and cerebellar atrophy in one (11%). Abnormal high intensity areas were observed on MRI in five patients (56%). The overall prevalence of brain abnormalities was 56% (5 of 9) on CT and 78% (7 of 9) on MRI scans. MRA revealed no stenotic lesions. SPECT showed reduced accumulation of [123I]IMP in the right or left parieto-occipital region in eight patients (89%).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Reduced accumulation of [123I]IMP in the parieto-occipital cortex was found in a high proportion of our subjects on SPECT. This imaging finding might be characteristic of diabetes associated with the 3243 mitochondrial tRNA mutation and may be a sign of latent central nervous system dysfunction.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/diacare.19.7.739","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"739-743","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":18,"title":["Diabetes With the 3243 Mitochondrial tRNALeu(UUR) Mutation: Characteristic neuroimaging findings"],"prefix":"10.2337","volume":"19","author":[{"given":"Yoshihiko","family":"Suzuki","sequence":"first","affiliation":[{"name":"Saiseikai Central Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kitazato University\u2008Sagamihara, Kanagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Miyaoka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Showa University\u2008Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Atsumi","sequence":"additional","affiliation":[{"name":"Saiseikai Central Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Kadowaki","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Care and Research, Asahi Life Foundation\u2008Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matsuo","family":"Taniyama","sequence":"additional","affiliation":[{"name":"Saiseikai Central Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takasi","family":"Kadowaki","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Showa University\u2008Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Odawara","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Tsukuba\u2008Tsukuba-City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Tokyo University\u2008Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Asahina","sequence":"additional","affiliation":[{"name":"Department of Medicine, Metabolism and Endocrinology, Juntendo University\u2008Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kempei","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Saiseikai Central Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/19\/7\/739\/515148\/19-7-739.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/19\/7\/739\/515148\/19-7-739.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T13:33:36Z","timestamp":1647092016000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/19\/7\/739\/19905\/Diabetes-With-the-3243-Mitochondrial-tRNALeu-UUR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1996,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.19.7.739","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7,1]]}}}