{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:40:19Z","timestamp":1760982019025},"reference-count":0,"publisher":"American Diabetes Association","issue":"2","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,2,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>The aim of this double-blind crossover study was to evaluate the effects of oral erythromycin (250 mg t.i.d.) on fasting and postprandial gastrointestinal motility and gastrointestinal symptoms in patients with type I diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Antroduodenal motility was recorded with an ambulatory manometric technique for a 20-h period, including a high-caloric high-fat dinner and a low-caloric low-fat breakfast and a long fasting period, after 2 weeks erythromycin and placebo treatment in 12 patients with type I diabetes. During the manometric study, plasma glucose concentrations were assessed by frequent self-testing. Gastrointestinal symptoms were scored daily to assess the severity of the symptoms (range 0\u20133).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Oral erythromycin decreased the migrating motor complex cycle length from 118.9 \u00b1 46.0 to 86.2 \u00b1 25.3 min (P = 0.03) by shortening phase II from 68.7 \u00b1 23.5 to 48.5 \u00b1 19.4 min (P &amp;lt; 0.05). The total number of duodenal phase III increased from 48 to 62 (P = 0.075). However, the degree of antral participation to duodenal phase III did not increase. Erythromycin significantly decreased the duration of the postprandial period after dinner (from 417.0 \u00b1 137.9 to 348.8 \u00b1 93.8 min, P = 0.04). During this shorter postprandial period, the number of antral contractions (P &amp;lt; 0.01) and the antral motility index increased (P &amp;lt; 0.03), and early phase III activity at the level of the duodenum was abolished. In diabetic patients with antral hypomotility, after dinner, the mean symptom score improved significantly, from 2.07 \u00b1 0.86 to 1.52 \u00b1 0.63 (P = 0.018).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>This ambulatory antroduodenal manometric study showed that oral erythromycin (250 mg t.i.d.) improves both fasting and postprandial antroduodenal motor activity after a high-caloric meal in patients with type I diabetes. Furthermore, in diabetic subjects with postprandial antral hypomotility, erythromycin reduces dyspeptic symptoms.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/diacare.20.2.129","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"129-134","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":25,"title":["Effects of Oral Erythromycin on Fasting and Postprandial Antroduodenal Motility in Patients With Type I Diabetes, Measured With an Ambulatory Manometric Technique"],"prefix":"10.2337","volume":"20","author":[{"given":"Melvin","family":"Samsom","sequence":"first","affiliation":[{"name":"Departments of Gastroenterology, University Hospital Utrecht\u2008Utrecht"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rik J A","family":"Jebbink","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology, University Hospital Utrecht\u2008Utrecht"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis M A","family":"Akkermans","sequence":"additional","affiliation":[{"name":"Departments of Surgery, University Hospital Utrecht\u2008Utrecht"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Bravenboer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Catharina Hospital Eindhoven\u2008Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard P","family":"Van Berge-Henegouwen","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology, University Hospital Utrecht\u2008Utrecht"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre J P M","family":"Smout","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology, University Hospital Utrecht\u2008Utrecht"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/20\/2\/129\/583774\/20-2-129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/20\/2\/129\/583774\/20-2-129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T12:11:49Z","timestamp":1647087109000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/20\/2\/129\/18851\/Effects-of-Oral-Erythromycin-on-Fasting-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,2,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.20.2.129","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2,1]]}}}