{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:08:08Z","timestamp":1761894488674},"reference-count":0,"publisher":"American Diabetes Association","issue":"3","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To investigate the long-term course of glomerular filtration rate (GFR) in IDDM patients with microalbuminuria in order to identify patients with stable or declining kidney function over a 5-year study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Forty normotensive (129 \u00b1 11\/80 \u00b1 8 mmHg) IDDM patients with persistent microalbuminuria (mean urinary albumin excretion [UAE] 84 mg\/24 h [range 30\u2013300]) were followed prospectively for 5 years of clinical examinations that included the measurement of GFR (51Cr-labeled EDTA clearance) at least once a year. The mean GFR at baseline was 120 \u00b1 18 ml \u00b7 min\u22121 \u00b7 1.73 m\u22122.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Using multiple regression analysis, the rate of decline in GFR was independently correlated to onset of diabetic nephropathy (P &amp;lt; 0.001) and systolic blood pressure (sBP) at baseline (P &amp;lt; 0.05). Increase in UAE was correlated to the mean HbA1c during the observation period. Out of 40 patients, 14 progressed to diabetic nephropathy (UAE &amp;gt; 300 mg\/24 h). These patients had a significant reduction in GFR (mean \u22122.2 \u00b1 3.8 ml \u00b7 min\u22121 \u00b7 year\u22121; P = 0.05), while GFR remained stable in the remaining 26 patients with nonprogressive microalbuminuria (change in GFR 0.5 \u00b1 2.1 ml \u00b7 min\u22121 \u00b7 year\u22121; NS). The difference in the rate of decline of GFR was significant (mean 2.7 ml \u00b7 min\u22121 \u00b7 year\u22121; P &amp;lt; 0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Normotensive IDDM patients with nonprogressive microalbuminuria have a stable GFR. Progression of UAE to diabetic nephropathy heralds a progressive loss of kidney function. Efforts should be made to prevent the progression from microalbuminuria to diabetic nephropathy in every IDDM patient with microalbuminuria.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/diacare.20.3.286","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"286-289","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":16,"title":["Stable Glomerular Filtration Rate in Normotensive IDDM Patients With Stable Microalbuminuria: A 5-year prospective study"],"prefix":"10.2337","volume":"20","author":[{"given":"Elisabeth R","family":"Mathiesen","sequence":"first","affiliation":[{"name":"Steno Diabetes Center\u2008Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Feldt-Rasmussen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center\u2008Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Hommel","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center\u2008Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Deckert","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center\u2008Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Henrik","family":"Parving","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center\u2008Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/20\/3\/286\/584013\/20-3-286.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/20\/3\/286\/584013\/20-3-286.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T14:24:48Z","timestamp":1647095088000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/20\/3\/286\/22191\/Stable-Glomerular-Filtration-Rate-in-Normotensive"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,3,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.20.3.286","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,3,1]]}}}