{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:57:28Z","timestamp":1789894648127,"version":"4.0.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>The symptoms of 430 type 2 diabetic patients were determined by a self-administered questionnaire before entry into the U.K. Prospective Diabetes Study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Entry into the trial followed 2 months of dietary treatment for newly diagnosed patients with type 2 diabetes. Forty symptoms with five levels of severity were included in the questionnaire. A complaint rate was computed as the sum of symptom scores divided by the number of symptom questions answered.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The complaint rate was independently and positively related to BMI, fasting plasma glucose (FPG), and being a woman. Three symptoms\u2014presence of dry mouth (P &amp;lt; 0.001), thirst (P &amp;lt; 0.01), and stomach pain (P = 0.02)\u2014were related to FPG independent of sex, age, BMI, or blood pressure. Only dry mouth was related to HbA1c (P = 0.05). Complaints of shortness of breath, swollen ankles, headaches, heartburn, sweating, wheezing, nocturia, thirst, and diarrhea increased with BMI independently of other variables. A complaint of cold extremities decreased with BMI. Heartburn, weakness of limbs, and hot flushes were positively related to blood pressure, and unsteadiness was negatively related.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The symptoms reported by patients with type 2 diabetes increased with FPG and markedly with BMI. The symptoms associated with obesity have been underestimated in the past.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/diacare.21.1.111","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"111-115","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":36,"title":["Association of Symptoms of Type 2 Diabetic Patients With Severity of Disease, Obesity, and Blood Pressure"],"prefix":"10.2337","volume":"21","author":[{"given":"Christopher J","family":"Bulpitt","sequence":"first","affiliation":[{"name":"Division of Geriatric Medicine, London School of Hygiene and Tropical Medicine\u2008London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J","family":"Palmer","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine, London School of Hygiene and Tropical Medicine\u2008London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Battersby","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine, London School of Hygiene and Tropical Medicine\u2008London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid E","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Royal Postgraduate Medical School, Hammersmith Hospital; and the Department of Epidemiology and Population Science, London School of Hygiene and Tropical Medicine\u2008London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/21\/1\/111\/585243\/21-1-111.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/21\/1\/111\/585243\/21-1-111.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T13:53:53Z","timestamp":1647093233000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/21\/1\/111\/19852\/Association-of-Symptoms-of-Type-2-Diabetic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.21.1.111","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1,1]]}}}