{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:05:56Z","timestamp":1760249156007},"reference-count":0,"publisher":"American Diabetes Association","issue":"9","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,9,1]]},"abstract":"\n OBJECTIVE<\/jats:title>\n We studied the relationship between vasoconstrictor changes in foot arteries (pedal, metatarsal, and digital arteries) and autonomic neuropathy in diabetic patients to estimate the degrees of sympathetic dysfunction.<\/jats:p>\n <\/jats:sec>\n \n RESEARCH DESIGN AND METHODS<\/jats:title>\n Sixty-two patients and nineteen age-matched control subjects were studied. The resistance index (RI) and pulsatility index (PI) were measured as vascular hemodynamic parameters using Doppler sonography, and the increases in these hemodynamic parameters (%RI and %PI) from rest to a deep breath were measured as indexes of the degrees of sympathetic vasoconstrictor function. Cardiovascular autonomic function tests (AFTs) were performed and the score was compared to %RI and %PI values obtained.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Of the 62 diabetic patients, 51 had various degrees of autonomic neuropathy. Both %RI and %PI in the diabetic patients were significantly &lt; those in the control subjects for all foot arteries tested (all P &lt; 0.001). There were strongly inverse correlations between the %RI and %PI of foot arteries and the AFT score (r = \u22120.556 to \u22120.846, P &lt; 0.0001). The %RI of the digital artery was the most strongly correlated with AFT score (r = \u22120.846, P &lt; 0.0001) among foot arteries tested. The abnormality of sympathetic vasoconstriction was detectable in the majority of the diabetic patients with the early phase of autonomic neuropathy (%RI: 89.5%; %PI: 94.5%).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n We conclude that the %RI of the digital artery is a useful and reliable sympathetic function test of early phase in diabetic patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/diacare.21.9.1495","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"1495-1501","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":9,"title":["Sympathetic Function Test of Vasoconstrictor Changes in Foot Arteries in Diabetic Patients"],"prefix":"10.2337","volume":"21","author":[{"given":"Tatsuji","family":"Takahashi","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine, Osaka City University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Osaka City University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Emoto","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Osaka City University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Kawagishi","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Osaka City University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Osaka City University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Ishimura","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Osaka City University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Inaba","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Osaka City University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Okuno","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Osaka City University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and Neurology, Osaka City University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotoshi","family":"Morii","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Osaka City University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/21\/9\/1495\/586671\/21-9-1495.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/21\/9\/1495\/586671\/21-9-1495.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T14:30:50Z","timestamp":1647095450000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/21\/9\/1495\/22336\/Sympathetic-Function-Test-of-Vasoconstrictor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1998,9,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.21.9.1495","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9,1]]}}}