{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:05:16Z","timestamp":1790089516013,"version":"4.0.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"7","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,7,1]]},"abstract":"OBJECTIVE: This population study examines the relationship between LDL density and persistent albuminuria in subjects with type 1 diabetes at the end of the Diabetes Control and Complications Trial (DCCT). RESEARCH DESIGN AND METHODS: Subjects were classified as persistently normoalbuminuric (albumin excretion rate [AER] &lt; 30 mg\/d, n = 1,056), microalbuminuric (AER &gt; or = 30-299 mg\/day, n = 80), and macroalbuminuric (AER = 300 mg\/day, n = 24) based on the last two AER measures. RESULTS: Triglyceride (P &lt; 0.01) and LDL cholesterol (P &lt; 0.01) levels were higher in macroalbuminuric subjects compared with normoalbuminuric subjects. Cholesterol distribution by density-gradient ultracentrifugation showed an increase in intermediate-density lipoprotein (IDL) and a shift in peak LDL from buoyant toward more dense particles with progressive albuminuria. In the entire group, there was a significant negative correlation between the peak buoyancy of LDL particles and albuminuria (r = -0.238, P &lt; 0.001, n = 1,160). This correlation persisted in the normoalbuminuric DCCT group (r = -0.138, P &lt; 0.001, n = 1,056). CONCLUSIONS: As albuminuria increases in subjects with type 1 diabetes, dyslipidemia occurs with an increase in IDL and dense LDL that may lead to increased cardiovascular disease.<\/jats:p>","DOI":"10.2337\/diacare.22.7.1165","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"1165-1170","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":45,"title":["Increased small dense LDL and intermediate-density lipoprotein with albuminuria in type 1 diabetes."],"prefix":"10.2337","volume":"22","author":[{"given":"S D","family":"Sibley","sequence":"first","affiliation":[{"name":"Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle 98195, USA. ssibley@u.washington.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E","family":"Hokanson","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle 98195, USA. ssibley@u.washington.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M W","family":"Steffes","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle 98195, USA. ssibley@u.washington.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Q","family":"Purnell","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle 98195, USA. ssibley@u.washington.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Marcovina","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle 98195, USA. ssibley@u.washington.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P A","family":"Cleary","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle 98195, USA. ssibley@u.washington.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J D","family":"Brunzell","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle 98195, USA. ssibley@u.washington.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/22\/7\/1165\/450096\/10388983.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/22\/7\/1165\/450096\/10388983.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T13:11:09Z","timestamp":1647090669000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/22\/7\/1165\/20350\/Increased-small-dense-LDL-and-intermediate-density"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.22.7.1165","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7,1]]}}}