{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:16:28Z","timestamp":1793823388821,"version":"4.6.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"12","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:p>OBJECTIVE: To observe the relationship of fasting plasma glucose (FPG), postchallenge plasma glucose (PG) (30, 60, 90, and 120 min during an oral glucose tolerance test [OGTT], as well as maximal PG during an OGTT, postchallenge glucose spikes [PGS], and glucose under the OGTT curve), and HbA1c to intima-media thickness (IMT) as a marker of atherosclerosis. RESEARCH DESIGN AND METHODS: OGTT, ultrasound measurement of carotid IMT, and various atherosclerosis risk factors, such as family history of diabetes, obesity, and\/or hyperlipoproteinemia, but without known diabetes, were analyzed in 582 individuals aged 40-70 years and at risk for type 2 diabetes. RESULTS: In univariate analysis, all examined glycemic parameters were significantly correlated to IMT. The 2-h postchallenge plasma glucose showed the strongest odds ratio (OR) of 1.88 (1.34-2.63) in relation to abnormal IMT. All PG variables, except for 30-min glucose in OGTT, showed a significant OR, whereas the OR for HbA1c and FPG was not significant. In logistic regression analysis, 2-h PG was identified as the strongest determinant of IMT from all glycemic parameters. The 2-h PG and PGS, but not FPG, were associated with a significant rise of IMT in tertiles of HbA1c. Glycemic parameters were strongly related to each other and to many atherosclerosis risk factors. In multivariate analysis including a variety of atherosclerosis risk factors, 2-h PG was a significant independent determinant of IMT. CONCLUSIONS: PG and PGS are more strongly associated with carotid IMT than FPG and HbA1c level and modify substantially the risk for atherosclerosis, estimated by HbA1c alone, in a cohort at risk for diabetes and in the early diabetes stage.<\/jats:p>","DOI":"10.2337\/diacare.23.12.1830","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T17:51:27Z","timestamp":1173117087000},"page":"1830-1834","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":439,"title":["Postchallenge plasma glucose and glycemic spikes are more strongly associated with atherosclerosis than fasting glucose or HbA1c level."],"prefix":"10.2337","volume":"23","author":[{"given":"T S","family":"Temelkova-Kurktschiev","sequence":"first","affiliation":[{"name":"Institute for Clinical Metabolic Research, Technical Univeristy Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Koehler","sequence":"additional","affiliation":[{"name":"Institute for Clinical Metabolic Research, Technical Univeristy Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Henkel","sequence":"additional","affiliation":[{"name":"Institute for Clinical Metabolic Research, Technical Univeristy Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Leonhardt","sequence":"additional","affiliation":[{"name":"Institute for Clinical Metabolic Research, Technical Univeristy Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Fuecker","sequence":"additional","affiliation":[{"name":"Institute for Clinical Metabolic Research, Technical Univeristy Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hanefeld","sequence":"additional","affiliation":[{"name":"Institute for Clinical Metabolic Research, Technical Univeristy Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/23\/12\/1830\/450554\/11128361.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/23\/12\/1830\/450554\/11128361.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T08:16:19Z","timestamp":1647072979000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/23\/12\/1830\/20470\/Postchallenge-plasma-glucose-and-glycemic-spikes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2000,12,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.23.12.1830","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12,1]]}}}