{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:48:27Z","timestamp":1791326907194,"version":"4.3.1"},"reference-count":30,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,1,1]]},"abstract":"<jats:p>OBJECTIVE\u2014 Because a pseudonormal pattern of ventricular filling has never been considered in studies that reported a prevalence of left ventricular diastolic dysfunction (LVDD) between 20 and 40%, our aim was to more completely evaluate the prevalence of LVDD in subjects with diabetes.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014 We studied 46 men with type 2 diabetes who were aged 38-67 years; without evidence of diabetic complications, hypertension, coronary artery disease, congestive heart failure, or thyroid or overt renal disease; and with a maximal treadmill exercise test showing no ischemia. LVDD was evaluated by Doppler echocardiography, which included the use of the Valsalva maneuver and pulmonary venous recordings to unmask a pseudonormal pattern of left ventricular filling.<\/jats:p>\n               <jats:p>RESULTS\u2014 LVDD was found in 28 subjects (60%), of whom 13 (28%)had a pseudonormal pattern of ventricular filling and 15 (32%) had impaired relaxation. Systolic function was normal in all subjects, and there was no correlation between LVDD and indexes of metabolic control.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014 LVDD is much more common than previously reported in subjects with well-controlled type 2 diabetes who are free of clinically detectable heart disease. The high prevalence of this phenomenon in this high-risk population suggests that screening for LVDD in type 2 diabetes should include procedures such as the Valsalva maneuver and pulmonary venous recordings to unmask a pseudonormal pattern of ventricular filling.<\/jats:p>","DOI":"10.2337\/diacare.24.1.5","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"5-10","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":457,"title":["Diastolic Dysfunction in Normotensive Men with Well-Controlled Type 2 Diabetes"],"prefix":"10.2337","volume":"24","author":[{"given":"Paul","family":"Poirier","sequence":"first","affiliation":[{"name":"From the Quebec Heart Institute and Laval Hospital, Sainte-Foy, Quebec,Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bogaty","sequence":"additional","affiliation":[{"name":"From the Quebec Heart Institute and Laval Hospital, Sainte-Foy, Quebec,Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Garneau","sequence":"additional","affiliation":[{"name":"From the Quebec Heart Institute and Laval Hospital, Sainte-Foy, Quebec,Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Marois","sequence":"additional","affiliation":[{"name":"From the Quebec Heart Institute and Laval Hospital, Sainte-Foy, Quebec,Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-G.","family":"Dumesnil","sequence":"additional","affiliation":[{"name":"From the Quebec Heart Institute and Laval Hospital, Sainte-Foy, Quebec,Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031214074402500_REF1","doi-asserted-by":"crossref","unstructured":"Kannel WB, Hjortland M, Castelli WP: Role of diabetes in congestive heart failure: the Framingham Study. 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