{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:36:10Z","timestamp":1791578170092,"version":"4.3.4"},"reference-count":28,"publisher":"American Diabetes Association","issue":"11","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,11,1]]},"abstract":"<jats:p>OBJECTIVE\u2014To evaluate the cumulative incidence of nephrotic-range albuminuria (NRA), the frequency of remission, and the impact on progression, we analyzed data from a prospective cohort study of type 1 diabetic patients with diabetic nephropathy.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014All of the albuminuric type 1 diabetic patients (n = 321, 121 women), who had at least yearly measurements of glomerular filtration rate (GFR) with a 51Cr-EDTA plasma clearance technique and were followed for at least 3 years, were evaluated. NRA, defined as persistent albuminuria &amp;gt;2,500 mg\/24 h, occurred in 126 patients (35 women) aged (mean \u00b1 SD) 34 \u00b1 8 years, with duration of diabetes 22 \u00b1 8 years and follow-up time from onset of NRA (median [range]) 8.7 (3.0\u201320.9) years. Remission of NRA was defined as sustained albuminuria &amp;lt;600 mg\/24 h for at least 1 year.<\/jats:p>\n               <jats:p>RESULTS\u2014The cumulative incidence of NRA was 39%. Remission was induced in 28 of 126 (22%) patients; 21 were predominantly treated with ACE inhibitors, 7 with non\u2013ACE inhibitor medications. Remission lasted 3.6 (1.0\u201318.1) years. More women (37%) than men (16%) obtained remission (P = 0.01). In the remission group compared with the no-remission group, mean arterial blood pressure (mean \u00b1 SEM) was reduced (102 \u00b1 1 vs. 106 \u00b1 1 mmHg, P &amp;lt; 0.01), the rate of decline in GFR was diminished (3.8 \u00b1 0.6 vs. 7.5 \u00b1 0.5 ml \u00b7 min\u20131 \u00b7 year\u20131, P &amp;lt; 0.001), and serum cholesterol was lower (5.3 \u00b1 0.2 vs. 6.1 \u00b1 0.1 mmol\/l, P &amp;lt; 0.01) during the whole follow-up period. No difference in glycemic control was found between groups (HbA1c 9.2 vs. 9.4%, NS).<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014In contrast to observations made before the use of antihypertensive treatment, our prospective observational study suggests that aggressive antihypertensive treatment with and without ACE inhibitors can induce long-lasting remission in a sizeable fraction of type 1 diabetic patients with NRA. The group of patients obtaining remission is characterized by slow progression of diabetic nephropathy and improved cardiovascular risk profile.<\/jats:p>","DOI":"10.2337\/diacare.24.11.1972","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"1972-1977","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":55,"title":["Remission of Nephrotic-Range Albuminuria in Type 1 Diabetic Patients"],"prefix":"10.2337","volume":"24","author":[{"given":"Peter","family":"Hovind","sequence":"first","affiliation":[{"name":"Steno Diabetes Center, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rossing","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Tarnow","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Toft","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeppe","family":"Parving","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Henrik","family":"Parving","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031216352714500_R1","unstructured":"Parving H-H, \u00d8sterby R, Ritz E: Diabetic nephropathy. 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