{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:29:22Z","timestamp":1791152962437,"version":"4.1.0"},"reference-count":28,"publisher":"American Diabetes Association","issue":"5","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,5,1]]},"abstract":"<jats:p>OBJECTIVE\u2014To investigate whether insulin is a risk factor for death by site-specific cancers.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014This was a prospective cohort study of 6,237 nondiabetic French working men between ages 44 and 55 years at baseline from the Paris Prospective Study cohort. Death by site-specific cancers was investigated in relation to baseline insulin concentrations during fasting and 2 h after a 75-g oral glucose tolerance test.<\/jats:p>\n               <jats:p>RESULTS\u2014Of the original 6,237 men in the cohort, 1,739 died over the 23.8 years of follow-up, 778 (45%) from cancer. Baseline hyperinsulinemia, both fasting and 2-h, was significantly associated with fatal liver cancer, with age-adjusted standardized hazards ratios of 2.72 (95% CI 1.87\u20133.94) and 3.41 (2.23\u20135.21). In contrast, fasting hyperinsulinemia was inversely associated with fatal lip, oral cavity, and pharynx cancer and larynx cancer, with hazards ratios of 0.55 (0.41\u20130.75) and 0.63 (0.47\u20130.83), respectively; 2-h insulin concentrations were inversely associated with stomach and larynx cancers (hazards ratios 0.62 [0.43\u20130.90] and 0.66 [0.50\u20130.89], respectively). These relationships were stable after adjusting for other risk factors. Insulin concentrations remained negatively associated with deaths from these cancers in analyses restricted to men who smoked and in those who were not chronic alcohol consumers.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014Peripheral hyperinsulinemia, indicative of very high portal insulin concentrations, predicted fatal liver cancer in these nondiabetic men, but was inversely associated with fatal lip, oral cavity, and pharynx cancer; stomach cancer; and larynx cancer.<\/jats:p>","DOI":"10.2337\/diacare.24.5.843","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"843-849","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":86,"title":["Hyperinsulinemia Predicts Fatal Liver Cancer but Is Inversely Associated With Fatal Cancer at Some Other Sites"],"prefix":"10.2337","volume":"24","author":[{"given":"Beverley","family":"Balkau","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unite\u0301 258 and the Faculty of Medicine, University Paris-Sud, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry S.","family":"Kahn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Courbon","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unite\u0301 258 and the Faculty of Medicine, University Paris-Sud, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"Eschwe\u0300ge","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unite\u0301 258 and the Faculty of Medicine, University Paris-Sud, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Ducimetie\u0300re","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) Unite\u0301 258 and the Faculty of Medicine, University Paris-Sud, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031216122624500_R1","doi-asserted-by":"crossref","unstructured":"Davey Smith G, Egger M, Shipley MJ, Marmot MG: Post-challenge glucose concentration, impaired glucose tolerance, diabetes and cancer mortality. 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