{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:33:42Z","timestamp":1776486822712,"version":"3.51.2"},"reference-count":31,"publisher":"American Diabetes Association","issue":"6","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,6,1]]},"abstract":"<jats:p>OBJECTIVE\u2014To describe the clinical course of individuals with idiopathic type 1 diabetes after a mean of 5 years from diagnosis and to compare glycemic control between those treated with diet and\/or oral agents and those treated with insulin at follow-up.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014Medical records of patients with new-onset diabetes, who presented with unprovoked diabetic ketoacidosis, were reviewed. A total of 54 of these individuals were traceable and had relevant data collected within the past 2 years. All patients had nonsusceptibility HLA haplotypes and no serological evidence of autoimmune type 1 diabetes. Most of these patients were male (41 men and 13 women), were non-Caucasian, were obese at the time of diagnosis (BMI 31.6 \u00b1 6.3 kg\/m2), reported weight loss (12.8 \u00b1 9.8 kg), had a family history of type 2 diabetes, and had acanthosis nigricans. At follow-up, 33 patients were still taking insulin and 21 were on diet and\/or oral-agent therapy.<\/jats:p>\n               <jats:p>RESULTS\u2014Both treatment groups were similar in clinical presentation and demographics at diagnosis. After 4.8 \u00b1 1.6 years of follow-up, the 33 patients that were receiving insulin had a lower HbA1c than the 21 patients who were using therapies other than insulin (7.8 \u00b1 2.4 vs. 11.1 \u00b1 3.5%, P = 0.009; 95% CI 1.0\u20136.5%). There was a high correlation between change in weight and change in HbA1c at follow-up (r = 0.45, P &amp;lt; 0.001, n = 54). There were no differences in the rate of diabetes complications or in the episodes of recurrent diabetic ketoacidosis.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014Idiopathic type 1 diabetes occurs more frequently in male African-American patients but also occurs in other ethnic groups. Patients with idiopathic type 1 diabetes who continued to use insulin had better glycemic control than patients using therapies other than insulin. Regained weight is a good clinical marker for improvement in glycemic control. Individuals with this type of diabetes should not be switched to therapies other than insulin.<\/jats:p>","DOI":"10.2337\/diacare.24.6.1014","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"1014-1018","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":70,"title":["Idiopathic Type 1 Diabetes in Dallas, Texas"],"prefix":"10.2337","volume":"24","author":[{"given":"Antonio","family":"Pin\u0303ero-Pilon\u0303a","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Litonjua","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Aviles-Santa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Raskin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","reference":[{"key":"2022031214495108300_R1","doi-asserted-by":"crossref","unstructured":"Winter WE, Maclaren N, Riley W, Clarke DW, Kappy MS, Spillar RP: Maturity onset diabetes of youth in black Americans. 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