{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:12:32Z","timestamp":1793293952913,"version":"4.5.0"},"reference-count":19,"publisher":"American Diabetes Association","issue":"8","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,8,1]]},"abstract":"<jats:p>OBJECTIVE\u2014The aim of this study was to quantify the distribution of peripheral arterial disease in the diabetic and nondiabetic population attending for angiography and to compare severity and outcome between both groups of patients.<\/jats:p>\n                  <jats:p>RESEARCH DESIGN AND METHODS\u2014Randomly selected lower-extremity angiograms were examined according to the Bollinger system. Patient demographics and medical history were recorded and case notes were examined to determine which patients later underwent a revascularization procedure or amputation and which patients had died.<\/jats:p>\n                  <jats:p>RESULTS\u2014A total of 136 arteriograms obtained between 1992 and 1996 were analyzed. The age (mean \u00b1 SD) of the patients was 64.7 \u00b1 10.8 years. Diabetic patients (43%) and nondiabetic patients were of similar age (63.9 \u00b1 10.4 vs. 65.3 \u00b1 11.1 years, P = 0.43), with a similar history of smoking (81.0 vs. 76.9%, P = 0.26), ischemic heart disease (41.4 vs. 37.2%, P = 0.54), and hypercholesterolemia (24.4 vs. 30.8%, P = 0.48). However, there were a greater proportion of hypertensive patients in the diabetic group (63.8 vs. 39.7%, P = 0.006). Diabetic patients had greater severity of arterial disease in the profunda femoris and all arterial segments below the knee (P = 0.02). A greater number of amputations occurred in the diabetic group: diabetic patients were five times more likely to have an amputation (41.4 vs. 11.5%, odds ratio [OR] 5.4, P &amp;lt; 0.0001). Mortality was higher in the diabetic group (51.7 vs. 25.6%, OR 3.1, P = 0.002), and diabetic patients who died were younger at presentation than nondiabetic patients (64.7 \u00b1 11.4 vs. 71.1 \u00b1 8.7 years, P = 0.04).<\/jats:p>\n                  <jats:p>CONCLUSIONS\u2014In patients with peripheral arterial disease, diabetic patients have worse arterial disease and a poorer outcome than nondiabetic patients.<\/jats:p>","DOI":"10.2337\/diacare.24.8.1433","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T17:51:27Z","timestamp":1173117087000},"page":"1433-1437","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":689,"title":["Peripheral Arterial Disease in Diabetic and Nondiabetic Patients"],"prefix":"10.2337","volume":"24","author":[{"given":"Edward B.","family":"Jude","sequence":"first","affiliation":[{"name":"Department of Medicine, Manchester Royal Infirmary, Manchester, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samson O.","family":"Oyibo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Manchester Royal Infirmary, Manchester, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Chalmers","sequence":"additional","affiliation":[{"name":"Department of Medicine, Manchester Royal Infirmary, Manchester, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.M.","family":"Boulton","sequence":"additional","affiliation":[{"name":"Department of Medicine, Manchester Royal Infirmary, Manchester, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031214393695300_R1","doi-asserted-by":"crossref","unstructured":"Ross R: The pathogenesis of artherosclerosis: an update. 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