{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T09:28:09Z","timestamp":1765704489334},"reference-count":26,"publisher":"American Diabetes Association","issue":"8","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,8,1]]},"abstract":"<jats:p>OBJECTIVE\u2014To examine whether the association between abdominal obesity and hyperglycemia differs according to the presence of a parental history of diabetes.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014We conducted a cross-sectional study of 3,068 men and women, aged 20\u201365 years, without known diabetes who were fasting participants of a population-based study in three Dutch towns. Hyperglycemia was defined as a fasting plasma glucose concentration of 6.1 mmol\/l (American Diabetes Association criterion). Waist circumference was categorized according to previously defined waist action levels. All estimates were adjusted for age and town.<\/jats:p>\n               <jats:p>RESULTS\u2014The regression coefficients for the association between waist circumference and fasting plasma glucose were larger in participants who had a parental history of diabetes than in those who did not (men \u03b2 = 0.31 vs. 0.16 mmol\/SD, P [for interaction] = 0.003; women \u03b2 = 0.24 vs. 0.11 mmol\/SD, P = 0.002). Furthermore, larger waist circumference (men \u226594 vs. &amp;lt;94 cm, women \u226588 vs. &amp;lt;80 cm) was associated with a greater excess prevalence of hyperglycemia in participants who had a parental history of diabetes than in those who did not (men 12.4 vs. 2.0%, P = 0.03; women 13.6 vs. 5.9%, P = 0.05). Adjustment for physical activity, alcohol intake, smoking, and educational level did not materially change the results.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014These findings indicate that the association between abdominal obesity and hyperglycemia is stronger in the presence of a parental history of diabetes. Blood glucose screening may be warranted at lower levels of waist circumference in individuals with a parental history of diabetes.<\/jats:p>","DOI":"10.2337\/diacare.24.8.1454","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"1454-1459","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":45,"title":["Parental History of Diabetes Modifies the Association Between Abdominal Adiposity and Hyperglycemia"],"prefix":"10.2337","volume":"24","author":[{"given":"Rob M.","family":"van Dam","sequence":"first","affiliation":[{"name":"Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanda M.A.","family":"Boer","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith J.M.","family":"Feskens","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaap C.","family":"Seidell","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven"},{"name":"Institute for Research in Extramural Medicine, Free University Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","reference":[{"key":"2022031214380846200_R1","doi-asserted-by":"crossref","unstructured":"Grill V, Persson G, Carlsson S, Norman A, Alvarsson M, O\u0308stensson CG, Svanstro\u0308m L, Efendic S: Family history of diabetes in middle-aged Swedish men is a gender unrelated factor which associates with insulinopenia in newly diagnosed diabetic subjects. 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