{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:21:26Z","timestamp":1792657286685,"version":"4.5.0"},"reference-count":26,"publisher":"American Diabetes Association","issue":"9","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,9,1]]},"abstract":"<jats:p>OBJECTIVE\u2014To determine the clinical and psychological course of diabetes through adolescence and the relationship with glycemic control in young adulthood.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014A longitudinal cohort study of adolescents recruited from the register of the outpatient pediatric diabetes clinic. A total of 76 individuals (43 male patients, 33 female patients) aged 11\u201318 years completed baseline assessments, and 65 individuals (86%) were reinterviewed as young adults (20\u201328 years of age). Longitudinal assessments were made of glycemic control (HbA1c), weight gain (BMI), and development of complications. Adolescents completed self-report questionnaires to assess emotional and behavioral problems as well as self-esteem. As young adults, psychological state was assessed by the Revised Clinical Interview Schedule and the self-report Brief Symptom Inventory.<\/jats:p>\n               <jats:p>RESULTS\u2014Mean HbA1c levels peaked in late adolescence and were worse in female participants (average 11.1% at 18\u201319 years of age). The proportion of individuals who were overweight (BMI &amp;gt;25.0 kg\/m2) increased during the 8-year period from 21 to 54% in female patients and from 2 to 28% in male patients. Serious diabetes-related events included death in one patient and cognitive impairment in two patients. Individuals in whom diabetic complications developed (25% of male patients and 38% of female patients) had significantly higher mean HbA1c levels than those without complications (difference 1.9%, 95% CI 1.1\u20132.7, P &amp;lt; 0.0001). Behavioral problems at baseline were related to higher mean HbA1c during the subsequent 8 years (\u03b2 = 0.15, SEM (\u03b2) 0.04, P &amp;lt; 0.001, 95% CI 0.07\u20130.24).<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014The outcome for this cohort was generally poor. Behavioral problems in adolescence seem to be important in influencing later glycemic control.<\/jats:p>","DOI":"10.2337\/diacare.24.9.1536","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"1536-1540","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":328,"title":["Clinical and Psychological Course of Diabetes From Adolescence to Young Adulthood"],"prefix":"10.2337","volume":"24","author":[{"given":"Kathryn S.","family":"Bryden","sequence":"first","affiliation":[{"name":"University Department of Paediatrics, John Radcliffe Hospital, Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Peveler","sequence":"additional","affiliation":[{"name":"Mental Health Group, Southampton"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Stein","sequence":"additional","affiliation":[{"name":"Leopold Muller Centre for Child and Family Mental Health, Royal Free and University College Medical School, UCL and Tavistock Clinic, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Neil","sequence":"additional","affiliation":[{"name":"Division of Public Health and Primary Health Care, University of Oxford, Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Mayou","sequence":"additional","affiliation":[{"name":"University Department of Psychiatry, Warneford Hospital, Oxford, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Dunger","sequence":"additional","affiliation":[{"name":"University Department of Paediatrics, John Radcliffe Hospital, Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031214195121700_R1","doi-asserted-by":"crossref","unstructured":"Mann NP, Johnston DI: Total glycosylated haemoglobin levels (HbA1) in diabetic children. 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