{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:44:35Z","timestamp":1777099475501,"version":"3.51.4"},"reference-count":40,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:p>OBJECTIVE\u2014Offspring born to women with pregnancies complicated by diabetes are at increased childhood risk of developing obesity and impaired glucose tolerance (IGT). In population-based studies, breast-feeding has been shown to be protective against obesity and diabetes later in life. To date, the role of breast-feeding on offspring of diabetic mothers (ODM) has not been investigated in this context.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014A total of 112 ODM (type 1 diabetes, n = 83; gestational diabetes, n = 29) were evaluated prospectively for impact of ingestion of either diabetic breast milk (DBM) or nondiabetic banked donor breast milk (BBM) during the early neonatal period (day 1\u20137 of life) on relative body weight and glucose tolerance at a mean age of 2 years.<\/jats:p>\n               <jats:p>RESULTS\u2014There was a positive correlation between the volume of DBM ingested and risk of overweight at 2 years of age (odds ratio [OR] 2.47, 95% CI 1.25\u20134.87). In contrast, the volume of BBM ingested was inversely correlated to body weight at follow-up (P = 0.001). Risk of childhood IGT decreased by increasing amounts of BBM ingested neonatally (OR 0.19, 95% CI 0.05\u20130.70). Stepwise regression analysis showed volume of DBM to be the only significant predictor of relative body weight at 2 years of age (P = 0.001).<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014Early neonatal ingestion of breast milk from diabetic mothers may increase risk of becoming overweight and, consequently, developing IGT during childhood. Additional studies are needed to assess long-term consequences that might result from the type of neonatal nutrition in ODM.<\/jats:p>","DOI":"10.2337\/diacare.25.1.16","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"16-22","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":165,"title":["Long-Term Impact of Neonatal Breast-Feeding on Body Weight and Glucose Tolerance in Children of Diabetic Mothers"],"prefix":"10.2337","volume":"25","author":[{"given":"Andreas","family":"Plagemann","sequence":"first","affiliation":[{"name":"Institute of Experimental Endocrinology, Humboldt University Medical School (Charite\u0301), Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Harder","sequence":"additional","affiliation":[{"name":"Institute of Experimental Endocrinology, Humboldt University Medical School (Charite\u0301), Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Franke","sequence":"additional","affiliation":[{"name":"Institute of Experimental Endocrinology, Humboldt University Medical School (Charite\u0301), Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Kohlhoff","sequence":"additional","affiliation":[{"name":"Clinic of Obstetrics and Gynecology, Berlin-Kaulsdorf, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","reference":[{"key":"2022031215141375200_R1","unstructured":"Do\u0308rner G: Influence of early postnatal nutrition on body height in adolescence. 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