{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:25:11Z","timestamp":1790745911340,"version":"4.1.0"},"reference-count":24,"publisher":"American Diabetes Association","issue":"8","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,8,1]]},"abstract":"<jats:p>OBJECTIVE\u2014To investigate the association between carotid atherosclerosis, measured as intima-media thickness (IMT), and cardiovascular morbidity in type 2 diabetic patients.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014We investigated the relationship between IMT and coronary artery disease (CAD) in 40 type 2 diabetic patients and 40 control subjects. Diabetic patients with CAD determined by coronary angiography were consecutively recruited, whereas the control subjects were recruited from among diabetic outpatients without CAD at the same institution. IMT was measured in both carotid arteries using B-mode ultrasonography.<\/jats:p>\n               <jats:p>RESULTS\u2014Carotid IMT was significantly greater in the diabetic patients than in the control subjects (1.27 \u00b1 0.07 vs. 1.03 \u00b1 0.04 mm, P &amp;lt; 0.05). IMT was associated with CAD by logistic regression analysis using all independent variables (P = 0.062). When the 40 patients with CAD were divided into a group of 20 patients with coronary artery bypass grafting (CABG) and another 20 patients without CABG, the IMT was significantly greater in the CABG group than in the non-CABG group (1.47 \u00b1 0.11 vs. 1.07 \u00b1 0.07 mm, P &amp;lt; 0.05).<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014These results indicate that the presence of carotid atherosclerosis implies a high probability of coronary involvement in Japanese nonobese subjects with type 2 diabetes.<\/jats:p>","DOI":"10.2337\/diacare.25.8.1308","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"1308-1312","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":49,"title":["Coronary Artery Disease and Carotid Artery Intima-Media Thickness in Japanese Type 2 Diabetic Patients"],"prefix":"10.2337","volume":"25","author":[{"given":"Naomi","family":"Mitsuhashi","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Metabolism and Endocrinology, Juntendo University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomio","family":"Onuma","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Metabolism and Endocrinology, Juntendo University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Kubo","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Metabolism and Endocrinology, Juntendo University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Takayanagi","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Metabolism and Endocrinology, Juntendo University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoe","family":"Honda","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Metabolism and Endocrinology, Juntendo University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuzo","family":"Kawamori","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Metabolism and Endocrinology, Juntendo University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031215022286800_R1","doi-asserted-by":"crossref","unstructured":"O\u2019Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr, the Cardiovascular Health Study Collaborative Research Group: Carotid artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. 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