{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T17:24:14Z","timestamp":1700241854944},"reference-count":31,"publisher":"American Diabetes Association","issue":"10","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,10,1]]},"abstract":"<jats:p>OBJECTIVE\u2014To study the relationships between the PC-1 K121Q variant and diabetic nephropathy (DN) in patients with type 2 diabetes.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014A total of 125 patients with type 2 diabetes and abnormal albumin excretion rate (AER) (range 20\u20135,416 \u03bcg\/min) were followed up for 4 years with repeated measurements of glomerular filtration rate (GFR). Genomic DNA was extracted from all patients, and the PC-1 K121Q polymorphism was determined by the PCR AvaII restriction enzyme. A subset of 64 patients underwent a percutaneous kidney biopsy at baseline, and glomerular structure was analyzed by electron microscopic morphometric analysis. At baseline, age (56 \u00b1 8 vs. 59 \u00b1 7 years), BMI (28.3 \u00b1 4.3 vs. 28.6 \u00b1 3.7 kg\/m2), known duration of type 2 diabetes (11.1 \u00b1 7 vs. 11.9 \u00b1 8 years), and HbA1c (8.6 \u00b1 1.8 vs. 8.4 \u00b1 1.7%) were similar in K121K (KK, n = 87, 73 men\/14 women) and XQ (35 K121Q + 3 Q121Q, n = 38, 27 men\/11 women) patients. Baseline GFR was 96 \u00b1 28 ml \u00b7 min\u22121 \u00b7 1.73 m\u22122 and was related (P = 0.01\u20130.001) to age, known diabetes duration, and systolic blood pressure.<\/jats:p>\n               <jats:p>RESULTS\u2014XQ patients had lower GFR (P &amp;lt; 0.05) than KK patients (88 \u00b1 30 vs. 100 \u00b1 26 ml \u00b7 min\u22121 \u00b7 1.73 m\u22122); this difference persisted also after factoring in age and known diabetes duration. The rate of progression of DN was similar in KK and XQ patients: %\u0394GFR was 4.1\/year (median, range: 22.9\u201330.6) vs. 4.2\/year (9.8\u201326.7). Morphometric parameters of diabetic glomerulopathy were similar in the two genotype groups.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014Among patients with type 2 diabetes with abnormal AER, those carrying the Q PC-1 genotype have more severe DN but not a faster GFR decline than KK patients, thus suggesting faster DN development since diabetes diagnosis in XQ patients.<\/jats:p>","DOI":"10.2337\/diacare.26.10.2898","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"2898-2902","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":12,"title":["PC-1 Amino Acid Variant Q121 Is Associated With a Lower Glomerular Filtration Rate in Type 2 Diabetic Patients With Abnormal Albumin Excretion Rates"],"prefix":"10.2337","volume":"26","author":[{"given":"Salvatore","family":"De Cosmo","sequence":"first","affiliation":[{"name":"Unit of Endocrinology, Scientific Institute \u201cCasa Sollievo della Sofferenza,\u201d San Giovanni Rotondo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Trevisan","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Padova, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Dalla Vestra","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Padova, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Vedovato","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Padova, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Argiolas","sequence":"additional","affiliation":[{"name":"Scientific Institute CSS-Mendel, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Solini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alois","family":"Saller","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Padova, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Damone","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Scientific Institute \u201cCasa Sollievo della Sofferenza,\u201d San Giovanni Rotondo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Tiengo","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Padova, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Trischitta","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Scientific Institute \u201cCasa Sollievo della Sofferenza,\u201d San Giovanni Rotondo, Italy"},{"name":"Department of Clinical Science, University \u201cLa Sapienza,\u201d Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Fioretto","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Padova, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","reference":[{"key":"2022031217540539500_R1","unstructured":"Viberti GC, Walker JD, Pinto J: Diabetic nephropathy. In International Textbook of Diabetes Mellitus. Alberti KGMM, DeFronzo RA, Keen H, Eds. Wiley, 1992, p. 1267\u20131328"},{"key":"2022031217540539500_R2","doi-asserted-by":"crossref","unstructured":"Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long term complications in insulin dependent diabetes mellitus. N Engl J Med\u2008329:977\u2013986, 1993","DOI":"10.1056\/NEJM199309303291401"},{"key":"2022031217540539500_R3","doi-asserted-by":"crossref","unstructured":"Stephenson M, Fuller JH, Viberti GC, Sjolie AK, Navalesi R: Blood pressure, retinopathy and urinary albumin excretion ratin IDDM: the EURODIAB Complications Study. 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Diabetes\u200849:1608\u20131611, 2000","DOI":"10.2337\/diabetes.49.9.1608"}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/26\/10\/2898\/590371\/dc1003002898.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/26\/10\/2898\/590371\/dc1003002898.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T18:48:21Z","timestamp":1647110901000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/26\/10\/2898\/26134\/PC-1-Amino-Acid-Variant-Q121-Is-Associated-With-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,1]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,10,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.26.10.2898","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,1]]}}}