{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:20:43Z","timestamp":1761708043010},"reference-count":29,"publisher":"American Diabetes Association","issue":"4","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,4,1]]},"abstract":"<jats:p>OBJECTIVE\u2014Isolated postchallenge hyperglycemia (IPH), defined as fasting plasma glucose (FPG) level &amp;lt;7.0 mmol\/l and 2-h plasma glucose (PG) level \u226511.1 mmol\/l, is a subtype of early-stage diabetes. This study evaluates the metabolic profiles of insulin secretion and insulin sensitivity in IPH to clarify the factors responsible for development of this form of type 2 diabetes.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014We conducted cross-sectional analysis of 231 Japanese men aged 20\u201370 years. The subjects were classified into the following three groups, based on the results of a 75-g oral glucose tolerance test (OGTT): 1) normal glucose tolerance (NGT), defined as FPG level &amp;lt;6.1 mmol\/l and 2-h PG level &amp;lt;7.8 mmol\/l (n = 89); 2) impaired glucose tolerance (IGT), defined as FPG level &amp;lt;7.0 mmol\/l and 2-h PG level of 7.8\u201311.1 mmol\/l (n = 94); and 3) IPH (n = 48). We compared the three groups for insulin secretion (insulinogenic index) and insulin sensitivity (index of insulin resistance using homeostasis model assessment [HOMA-IR]).<\/jats:p>\n               <jats:p>RESULTS\u2014The insulinogenic index in IPH was the lowest of the three groups (P &amp;lt; 0.001 versus NGT). The HOMA-IR in the IGT and IPH groups were significantly higher than in the NGT group (P &amp;lt; 0.001), but both were similar. By linear regression analysis, the insulinogenic index rather than fasting insulin or HOMA-IR was the more significant factor in the 2-h PG level in IGT and IPH.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014Subjects with IPH exhibited distinctly impaired early-phase insulin secretion and only mild insulin resistance, indicating that reduced insulin secretion is the primary determinant of deterioration from NGT to IGT and IPH in development of type 2 diabetes in these subjects.<\/jats:p>","DOI":"10.2337\/diacare.26.4.1211","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"1211-1215","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":57,"title":["Factors Responsible for Development From Normal Glucose Tolerance to Isolated Postchallenge Hyperglycemia"],"prefix":"10.2337","volume":"26","author":[{"given":"Haruhiko","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Usami","sequence":"additional","affiliation":[{"name":"Ikeda Hospital, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Ikeda Hospital, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ataru","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Kansai-Denryoku Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosikatsu","family":"Nakai","sequence":"additional","affiliation":[{"name":"College of Medical Technology, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Kansai Health Management Center, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kuroe","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kurose","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Seino","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","reference":[{"key":"2022031216131382800_R1","doi-asserted-by":"crossref","unstructured":"Donahue RP, Abbott RD, Reed DM, Yano K: Postchallenge glucose concentration and coronary heart disease in men of Japanese ancestry: Honolulu Heart Program. 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