{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T03:04:35Z","timestamp":1787454275415,"version":"build-2736575974"},"reference-count":41,"publisher":"American Diabetes Association","issue":"7","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,7,1]]},"abstract":"<jats:p>OBJECTIVE\u2014Routine screening of diabetic patients with echocardiography is not feasible due to its limited availability and high cost. B-type natriuretic peptide (BNP) is secreted from the left ventricle in response to pressure overload and is elevated in both systolic and diastolic dysfunction.<\/jats:p>\n                  <jats:p>RESEARCH DESIGN AND METHODS\u2014BNP levels were compared to echocardiographic findings in 263 patients. Patients were divided into two groups: clinical indication for echocardiography (CIE) (n = 172) and those without clinical indication for echocardiography (no-CIE) (n = 91). Cardiologists making the assessment of left ventricular function were blinded when measuring plasma levels of BNP.<\/jats:p>\n                  <jats:p>RESULTS\u2014The 91 patients with no-CIE with echos had similar BNP levels (83 \u00b1 16 pg\/ml) to the 215 patients with no-CIE without echos (63 \u00b1 10, P = 0.10). Patients with CIE and subsequent abnormal left ventricular function (n = 112) had a mean BNP concentration of 435 \u00b1 41 pg\/ml, compared with those with no-CIE, but had abnormal left ventricular function on echo (n = 32) (161 \u00b1 40 pg\/ml). Twenty-one of 32 patients with no-CIE but with abnormal left ventricular function had diastolic dysfunction (BNP 190 \u00b1 60pg\/ml). A receiver-operating characteristic (ROC) curve revealed that the area under the curve was 0.91 for CIE patients and 0.81 for no-CIE patients (P &amp;lt; 0.001). For those with no congestive heart failure (CHF) symptoms, BNP levels showed a high negative predictive value (91% for BNP values &amp;lt;39 pg\/ml), while in those patients who had a CIE, BNP levels showed a high positive predictive value for the detection of left ventricular dysfunction (96% with BNP levels &amp;gt;90 pg\/ml).<\/jats:p>\n                  <jats:p>CONCLUSIONS\u2014BNP can reliably screen diabetic patients for the presence or absence of left ventricular dysfunction.<\/jats:p>","DOI":"10.2337\/diacare.26.7.2081","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T17:51:27Z","timestamp":1173117087000},"page":"2081-2087","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":105,"title":["Utility of B-Type Natriuretic Peptide (BNP) as a Screen for Left Ventricular Dysfunction in Patients With Diabetes"],"prefix":"10.2337","volume":"26","author":[{"given":"Victoria","family":"Epshteyn","sequence":"first","affiliation":[{"name":"Department of Medicine, Veteran\u2019s Affairs Medical Center, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veteran\u2019s Affairs Medical Center, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padma","family":"Krishnaswamy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veteran\u2019s Affairs Medical Center, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radmila","family":"Kazanegra","sequence":"additional","affiliation":[{"name":"Biosite Diagnostics, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Clopton","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veteran\u2019s Affairs Medical Center, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunder","family":"Mudaliar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veteran\u2019s Affairs Medical Center, San Diego, California"},{"name":"University of California, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Edelman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veteran\u2019s Affairs Medical Center, San Diego, California"},{"name":"University of California, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Henry","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veteran\u2019s Affairs Medical Center, San Diego, California"},{"name":"University of California, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Maisel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veteran\u2019s Affairs Medical Center, San Diego, California"},{"name":"University of California, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031217240676500_R1","unstructured":"Eschwege E, Simon D, Balkau B: The growing burden of diabetes in the world population. International Diabetes Federation Bulletin\u200842:14\u201319, 1997"},{"key":"2022031217240676500_R2","unstructured":"Centers for Disease Control and Prevention: National Estimates and General Information on Diabetes in the United States: Diabetes Fact Sheet. Atlanta, GA, US Dept of Health and Human Services, Centers of Disease Control and Prevention, 1997"},{"key":"2022031217240676500_R3","doi-asserted-by":"crossref","unstructured":"Stamler J, Vaccaro O, Neaton JD, Wentworth D: Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care\u200816:434\u2013444, 1993","DOI":"10.2337\/diacare.16.2.434"},{"key":"2022031217240676500_R4","doi-asserted-by":"crossref","unstructured":"Nichols GA, Hillier TA, Erbey JR, Brown JB: Congestive heart failure in type 2 diabetes: prevalence, incidence, and risk factors. Diabetes Care\u200824:1614\u20131619, 2001","DOI":"10.2337\/diacare.24.9.1614"},{"key":"2022031217240676500_R5","doi-asserted-by":"crossref","unstructured":"Galderisi M, Anderson KM, Wilson PW, Levy D: Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (the Framingham Heart Study). Am J Cardiology\u200868:85\u201389, 1991","DOI":"10.1016\/0002-9149(91)90716-X"},{"key":"2022031217240676500_R6","doi-asserted-by":"crossref","unstructured":"Senni M, Rodeheffer RJ, Tribouilloy CM, Evans JM, Jacobsen SJ, Baily KR, Redfield MM: Use of echocardiography in the management of congestive heart failure in the community. J Am Coll Cardiol\u200833:124\u2013170, 1999","DOI":"10.1016\/S0735-1097(98)00523-3"},{"key":"2022031217240676500_R7","doi-asserted-by":"crossref","unstructured":"Maeda K, Tsutamoto T, Wada A, Hisanaga T, Kinoshita M : Plasma brain natriuretic peptide as a biochemical marker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dysfunction. Am Heart J\u2008135:825\u2013832, 1998","DOI":"10.1016\/S0002-8703(98)70041-9"},{"key":"2022031217240676500_R8","doi-asserted-by":"crossref","unstructured":"Harrison A, Morrison LK, Krishnaswamy P, Kazanegra R, Clopton P, Dao Q, Hlavin P, Maisel AS: B-type natriuretic peptide (BNP) predicts future cardiac events in patients presenting to the emergency department with dyspnea. Ann of Emerg Med\u200839:131\u2013138, 2002","DOI":"10.1067\/mem.2002.121483"},{"key":"2022031217240676500_R9","doi-asserted-by":"crossref","unstructured":"Maisel AS, Koon J, Krishnaswamy P, Kazenegra R, Clopton P, Gardetto N, Morrisey R, Garcia A, Chiu A, De Maria A: Utility of B-natriuretic peptide (BNP) as a rapid, point-of-care test for screening patients undergoing echocardiography for left ventricular dysfunction. Am Heart J\u2008141:367\u2013374, 2001","DOI":"10.1067\/mhj.2001.113215"},{"key":"2022031217240676500_R10","doi-asserted-by":"crossref","unstructured":"Krishnaswamy P, Lubien E, Clopton P, Koon J, Kazenegra R, Wanner E, Gardetto N, Garcia A, de Maria A, Maisel AS: Utility of B-natriuretic peptide (BNP) in elucidating left ventricular dysfunction (systolic and diastolic) in patients with and without symptoms of congestive heart failure at a Veterans hospital. Am J Med\u2008111:274\u2013279, 2002","DOI":"10.1016\/S0002-9343(01)00841-5"},{"key":"2022031217240676500_R11","doi-asserted-by":"crossref","unstructured":"Lubien E, DeMaria A, Krishnaswamy P, Clopton P, Koon J, Kazanegra R, Gardetto N, Wanner E, Maisel AS: Utility of B-natriuretic peptide in detecting diastolic dysfunction: comparison with Doppler velocity recordings. Circulation\u2008105:595\u2013601, 2002","DOI":"10.1161\/hc0502.103010"},{"key":"2022031217240676500_R12","unstructured":"Feigenbaum H: Echocardiography. 6th ed. Philadelphia, Lea & Febiger, 1999"},{"key":"2022031217240676500_R13","doi-asserted-by":"crossref","unstructured":"Schiller NB, Acquatella H, Ports TA, Drew D, Goerke J, Ringertz H, Silverman NH, Brundage B, Botvinick EH, Boswell R, Carlsson E, Parmley WW : Left ventricular volume from paired biplane two-dimensional echocardiography. Circulation\u200860:547\u2013555, 1979","DOI":"10.1161\/01.CIR.60.3.547"},{"key":"2022031217240676500_R14","doi-asserted-by":"crossref","unstructured":"Wieczorek SJ, Wu AH, Christenson R, Krishnaswamy P, Gottlieb S, Rosano T, Hager D, Gardetto N, Bailly KR, Maisel AS: A rapid B-Type natriuretic peptide (BNP) assay accurately diagnoses left ventricular dysfunction and heart failure: a multi-center evaluation. Am Heart J\u2008144:834\u2013839, 2002","DOI":"10.1067\/mhj.2002.125623"},{"key":"2022031217240676500_R15","doi-asserted-by":"crossref","unstructured":"Cheng VL, Krishnaswamy P, Kazanegra R, Garcia A, Gardetto N, Maisel AS: A rapid bedside test for b-type natriuretic peptide predicts treatment outcomes in patients admitted with decompensated heart failure. 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