{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:18:57Z","timestamp":1776953937042,"version":"3.51.4"},"reference-count":49,"publisher":"American Diabetes Association","issue":"3","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,3,1]]},"abstract":"<jats:p>OBJECTIVE\u2014To evaluate the expression of connective tissue growth factor (CTGF) and its fragments in the vitreous of patients with proliferative diabetic retinopathy (PDR) and to localize CTGF expression in associated preretinal membranes.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014Vitreous was obtained from 24 patients with active PDR, 4 patients with quiescent PDR, and 23 patients with other retinal diseases and no diabetes, including 5 patients with vitreous hemorrhage. Enzyme-linked immunosorbent assay was used to determine levels of whole CTGF and its NH2- and COOH-terminal fragments. Preretinal membranes from three patients with active PDR were stained immunohistochemically for the presence of CTGF and cell type-specific markers.<\/jats:p>\n               <jats:p>RESULTS\u2014A significant increase in NH2-terminal CTGF fragment content was found in vitreous samples from patients with active PDR when compared with samples from nondiabetic patients (P &amp;lt; 0.0001) or patients with quiescent PDR (P = 0.02). Levels of NH2-terminal CTGF were also greater in vitreous samples from diabetic patients with vitreous hemorrhage compared with samples from nondiabetic patients with vitreous hemorrhage (P = 0.02). Vitreous levels of whole CTGF were similar in all groups. COOH-terminal fragments of CTGF were not detected. CTGF immunoreactivity was predominantly localized to smooth muscle actin-positive myofibroblasts within active PDR membranes.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014NH2-terminal CTGF fragment content is increased in the vitreous of patients with active PDR, suggesting that it plays a pathogenic role or represents a surrogate marker of CTGF activity in the disorder. The localization of CTGF in myofibroblasts suggests a local paracrine mechanism for induction of fibrosis and neovascularization.<\/jats:p>","DOI":"10.2337\/diacare.27.3.758","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"758-764","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":63,"title":["Accumulation of NH2-Terminal Fragment of Connective Tissue Growth Factor in the Vitreous of Patients With Proliferative Diabetic Retinopathy"],"prefix":"10.2337","volume":"27","author":[{"given":"David R.","family":"Hinton","sequence":"first","affiliation":[{"name":"Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California"},{"name":"Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California"},{"name":"Beckman Macular Research Center at the Doheny Eye Institute, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Spee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shikun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Weitz","sequence":"additional","affiliation":[{"name":"Beckman Macular Research Center at the Doheny Eye Institute, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Usinger","sequence":"additional","affiliation":[{"name":"FibroGen, South San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"LaBree","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelynn","family":"Oliver","sequence":"additional","affiliation":[{"name":"FibroGen, South San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer I.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","reference":[{"key":"2022031215231199600_R1","doi-asserted-by":"crossref","unstructured":"Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL 3rd, Klein R: Diabetic retinopathy. Diabetes Care\u200826 (Suppl. 1):S99\u2013S102, 2003","DOI":"10.2337\/diacare.26.2007.S99"},{"key":"2022031215231199600_R2","doi-asserted-by":"crossref","unstructured":"Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Levison SW: Diabetic retinopathy: more than meets the eye. Surv Ophthalmol\u200847 (Suppl. 2):S253\u2013S262, 2002","DOI":"10.1016\/S0039-6257(02)00387-9"},{"key":"2022031215231199600_R3","doi-asserted-by":"crossref","unstructured":"Aiello LP, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL 3rd, Klein R: Diabetic retinopathy (Technical Review). Diabetes Care\u200821:143\u2013156, 1998","DOI":"10.2337\/diacare.21.1.143"},{"key":"2022031215231199600_R4","doi-asserted-by":"crossref","unstructured":"Nakanishi T, Koyama R, Ikeda T, Shimizu A: Catalogue of soluble proteins in the human vitreous humor: comparison between diabetic retinopathy and macular hole. J Chromatogr B Analyt Technol Biomed Life Sci\u2008776:89\u2013100, 2002","DOI":"10.1016\/S1570-0232(02)00078-8"},{"key":"2022031215231199600_R5","doi-asserted-by":"crossref","unstructured":"Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE, Nguyen HV, Aiello LM, Ferrara N, King G: Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med\u2008331:1480\u20131487, 1994","DOI":"10.1056\/NEJM199412013312203"},{"key":"2022031215231199600_R6","doi-asserted-by":"crossref","unstructured":"Adamis AP, Miller JW, Bernal MT, D\u2019Amico DJ, Folkman J, Yeo TK, Yeo KT: Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol\u2008118:445\u2013450, 1994","DOI":"10.1016\/S0002-9394(14)75794-0"},{"key":"2022031215231199600_R7","doi-asserted-by":"crossref","unstructured":"Katsura Y, Okano T, Noritake M, Kosano H, Nishigori H, Kado S, Matsuoka T: Hepatocyte growth factor in vitreous fluid of patients with proliferative diabetic retinopathy and other retinal disorders. Diabetes Care\u200821:1759\u20131763, 1998","DOI":"10.2337\/diacare.21.10.1759"},{"key":"2022031215231199600_R8","doi-asserted-by":"crossref","unstructured":"Umeda N, Ozaki H, Hayashi H, Kondo H, Uchida H, Oshima K: Non-paralleled increase of hepatocyte growth factor and vascular endothelial growth factor in the eyes with angiogenic and nonangiogenic fibroproliferation. Ophthalmic Res\u200834:43\u201347, 2002","DOI":"10.1159\/000048324"},{"key":"2022031215231199600_R9","doi-asserted-by":"crossref","unstructured":"Simo R, Lecube A, Segura RM, Garcia Arumi J, Hernandez C: Free insulin growth factor-1 and vascular endothelial growth factor in the vitreous fluid of patients with proliferative diabetic retinopathy. Am J Ophthalmol\u2008134:376\u2013382, 2002","DOI":"10.1016\/S0002-9394(02)01538-6"},{"key":"2022031215231199600_R10","doi-asserted-by":"crossref","unstructured":"Freyberger H, Brocker M, Yakut H, Hammer J, Effert R, Schifferdecker E, Schatz H, Derwahl M: Increased levels of platelet-derived growth factor in vitreous fluid of patients with proliferative diabetic retinopathy. Exp Clin Endocrinol Diabetes\u2008108:106\u2013109, 2000","DOI":"10.1055\/s-2000-5803"},{"key":"2022031215231199600_R11","doi-asserted-by":"crossref","unstructured":"Ogata N, Tombran-Tink J, Nishikawa M, Nishimura T, Mitsuma Y, Sakamoto T, Matsumura M: Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment. Am J Opththalmol\u2008132:378\u2013382, 2001","DOI":"10.1016\/S0002-9394(01)01008-X"},{"key":"2022031215231199600_R12","doi-asserted-by":"crossref","unstructured":"Ogata N, Nishikawa M, Nishimura T, Mitsuma Y, Matsumura M: Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy. Am J Ophthalmol\u2008134:348\u2013353, 2002","DOI":"10.1016\/S0002-9394(02)01568-4"},{"key":"2022031215231199600_R13","doi-asserted-by":"crossref","unstructured":"Simo R, Lecube A, Sararols L, Garcia-Arumi J, Segura RM, Casamitjana R, Hernandez C: Deficit of somatostatin-like immunoreactivity in the vitreous fluid of diabetic patients: possible role in the development of proliferative diabetic retinopathy. Diabetes Care\u200825:2282\u20132286, 2002","DOI":"10.2337\/diacare.25.12.2282"},{"key":"2022031215231199600_R14","doi-asserted-by":"crossref","unstructured":"Beranek M, Kankova K, Benes P, Izakovicova-Holla L, Znojil V, Hajek D, Vlkova E, Vacha J: Polymorphism R25P in the gene encoding transforming growth factor-beta (TGF-beta 1) is a newly identified risk factor for proliferative diabetic retinopathy. Am J Med Genet\u2008109:278\u2013283, 2002","DOI":"10.1002\/ajmg.10372"},{"key":"2022031215231199600_R15","doi-asserted-by":"crossref","unstructured":"Boulton M, Gregor Z, McLeod D, Charteris D, Jarvis-Evans J, Moriarty P, Khaliq A, Foreman D, Allamby D, Bardsley B: Intravitreal growth factors in proliferative diabetic retinopathy: correlation with neovascular activity and glycaemic management. Br J Ophthalmol\u200881:228\u2013233, 1997","DOI":"10.1136\/bjo.81.3.228"},{"key":"2022031215231199600_R16","doi-asserted-by":"crossref","unstructured":"Hirase K, Ikeda T, Sotozono C, Nishida K, Sawa H, Kinoshita S: Transforming growth factor beta2 in the vitreous in proliferative diabetic retinopathy. Arch Ophthalmol\u2008116:738\u2013741, 1998","DOI":"10.1001\/archopht.116.6.738"},{"key":"2022031215231199600_R17","doi-asserted-by":"crossref","unstructured":"Pfeiffer A, Spranger J, Meyer-Schwickerath R, Schatz H: Growth factor alterations in advanced diabetic retinopathy: a possible role of blood retina barrier breakdown. Diabetes\u200846 (Suppl. 2):S26\u2013S30, 1997","DOI":"10.2337\/diab.46.2.S26"},{"key":"2022031215231199600_R18","doi-asserted-by":"crossref","unstructured":"Spranger J, Meyer-Schwickerath R, Klein M, Schatz H, Pfeiffer A: Deficient activation and different expression of transforming growth factor-beta isoforms in active proliferative diabetic retinopathy and neovascular eye disease. Exp Clin Endocrinol Diabetes\u2008107:21\u201328, 1999","DOI":"10.1055\/s-0029-1212068"},{"key":"2022031215231199600_R19","doi-asserted-by":"crossref","unstructured":"Leask A, Holmes A, Abraham DJ: Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis. Curr Rheumatol Rep\u20084:136\u2013142, 2002","DOI":"10.1007\/s11926-002-0009-x"},{"key":"2022031215231199600_R20","doi-asserted-by":"crossref","unstructured":"Bradham DM, Igarashi A, Potter RL, Grotendorst GR: Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol\u2008114:1285\u20131294, 1991","DOI":"10.1083\/jcb.114.6.1285"},{"key":"2022031215231199600_R21","doi-asserted-by":"crossref","unstructured":"Moussad EEA, Brigstock DR: Connective tissue growth factor: what\u2019s in a name? Mol Genet Metab\u200871:276\u2013292, 2000","DOI":"10.1006\/mgme.2000.3059"},{"key":"2022031215231199600_R22","doi-asserted-by":"crossref","unstructured":"Perbal B: NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues. Mol Pathol\u200854:57\u201379, 2001","DOI":"10.1136\/mp.54.2.57"},{"key":"2022031215231199600_R23","unstructured":"Ryseck R-P, Macdonald-Bravo H, Mattei M-G, Bravo R: Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein. Cell Growth Differ\u20082:225\u2013233, 1991"},{"key":"2022031215231199600_R24","doi-asserted-by":"crossref","unstructured":"Frazier K, Williams S, Kothapalli D, Klapper H, Grotendorst GR: Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J Invest Dermatol\u2008107:404\u2013411, 1996","DOI":"10.1111\/1523-1747.ep12363389"},{"key":"2022031215231199600_R25","doi-asserted-by":"crossref","unstructured":"Abreu JG, Ketpura NI, Reversade B, De Robertis EM: Connective tissue growth factor (CTGF) modulates cell signaling by BMP and TGF-beta. Nat Cell Biol\u20084:599\u2013604, 2002","DOI":"10.1038\/ncb826"},{"key":"2022031215231199600_R26","doi-asserted-by":"crossref","unstructured":"Steffen CL, Ball-Mirth DK, Harding PA, Bhattacharyya N, Pillai S, Brigstock DR: Characterization of cell-associated and soluble forms of connective tissue growth factor (CTGF) produced by fibroblast cells in vitro. Growth Factors\u200815:199\u2013213, 1998","DOI":"10.3109\/08977199809002117"},{"key":"2022031215231199600_R27","doi-asserted-by":"crossref","unstructured":"Yang DH, Kim HS, Wilson EM, Rosenfeld RG, Oh Y: Identification of glycolyslated 38-kDa connective tissue growth factor (IGFBP-related protein 2) and proteolytic fragments in human biological fluids, and up-regulation of IGFBP-rP2 expression by TGF-\u03b2 in Hs578T human breast cancer cells. J Endocrinol Metab\u200883:2593\u20132596, 1998","DOI":"10.1210\/jc.83.7.2593"},{"key":"2022031215231199600_R28","doi-asserted-by":"crossref","unstructured":"Ball DK, Surveyor GA, Diehl JR, Steffen CL, Uzumcu M, Mirando MA, Brigstock DR: Characterization of 16- to 20-kilodalton (kDa) connective tissue growth factors (CTGFs) and demonstration of proteolytic activity for 38-kDa CTGF in pig uterine luminal washings. Biol Reprod\u200859:828\u2013835, 1998","DOI":"10.1095\/biolreprod59.4.828"},{"key":"2022031215231199600_R29","doi-asserted-by":"crossref","unstructured":"Shimo T, Nakanishi T, Nishida T, Asano M, Kanyama M, Kuboki T, Tamatani T, Tezuka K, Takemura M, Matsumura T, Takigawa M: Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo. J Biochem (Tokyo)\u2008126:137\u2013145, 1999","DOI":"10.1093\/oxfordjournals.jbchem.a022414"},{"key":"2022031215231199600_R30","doi-asserted-by":"crossref","unstructured":"Babic AM, Chen CC, Lau LF: Fisp 12\/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin \u03b1V\u03b23, promotes endothelial cell survival, and induces angiogenesis. Mol Cell Biol\u200819:2958\u20132966, 1999","DOI":"10.1128\/MCB.19.4.2958"},{"key":"2022031215231199600_R31","doi-asserted-by":"crossref","unstructured":"Shimo T, Nakanishi T, Kimura Y, Nishida T, Ishizeki K, Matsumura T, Takigawa M: Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells. J Biochem (Tokyo)\u2008124:130\u2013140, 1998","DOI":"10.1093\/oxfordjournals.jbchem.a022071"},{"key":"2022031215231199600_R32","doi-asserted-by":"crossref","unstructured":"Inoki I, Shiomi T, Hashimoto G, Enomoto H, Nakamura H, Makino K, Ikeda E, Takata S, Kobayashi K, Okada Y: Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. FASEB J\u200816:219\u2013221, 2002","DOI":"10.1096\/fj.01-0332fje"},{"key":"2022031215231199600_R33","doi-asserted-by":"crossref","unstructured":"Hinton DR, He S, Jin ML, Barron E, Ryan SJ: Novel growth factors involved in the pathogenesis of proliferative vitreoretinopathy. Eye\u200816:422\u2013428, 2002","DOI":"10.1038\/sj.eye.6700190"},{"key":"2022031215231199600_R34","unstructured":"Tikellis C, Cooper ME, Twigg SM, Burns WC, Tolcos M: Connective tissue growth factor is up-regulated in the diabetic retina: amelioration by ACE inhibition. Endocrinol, 2003 (Epub ahead of print at Endocrinol,2003,10.1210\/en.2003-0967)"},{"key":"2022031215231199600_R35","doi-asserted-by":"crossref","unstructured":"Suzuma K, Naruse K, Suzuma I, Takahara N, Ueki K, Aiello LP, King GL: Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1 and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells. J Biol Chem\u2008275:40725\u201340731, 2000","DOI":"10.1074\/jbc.M006509200"},{"key":"2022031215231199600_R36","doi-asserted-by":"crossref","unstructured":"Wunderlich K, Senn BC, Todesco L, Flammer J, Meyer P: Regulation of connective tissue growth factor gene expression in retinal vascular endothelial cells by angiogenic growth factors: Graefes Arch Clin Exp Ophthalmol\u2008238:910\u2013915, 2000","DOI":"10.1007\/s004170000199"},{"key":"2022031215231199600_R37","doi-asserted-by":"crossref","unstructured":"Tamatani T, Kobayashi H, Tezuka K, Sakamoto S, Suzuki K, Nakanishi T, Takigawa M, Miyano T: Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia. Biochem Biophys Res Commun\u2008251:748\u2013752, 1998","DOI":"10.1006\/bbrc.1998.9543"},{"key":"2022031215231199600_R38","doi-asserted-by":"crossref","unstructured":"Hashimoto G, Inoki I, Fujii Y, Aoki T, Ikeda E, Okada Y: Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165. J Biol Chem\u2008227:36288\u201336295, 2002","DOI":"10.1074\/jbc.M201674200"},{"key":"2022031215231199600_R39","doi-asserted-by":"crossref","unstructured":"Jin M, Kashiwagi K, Iizuki Y, Tanaka Y, Imai M, Tsukahara S: Matrix metalloproteinases in human diabetic and nondiabetic vitreous. Retina\u200821:28\u201333, 2001","DOI":"10.1097\/00006982-200102000-00005"},{"key":"2022031215231199600_R40","doi-asserted-by":"crossref","unstructured":"He S, Jin ML, Worpel V, Hinton DR: A role of connective tissue growth factor in the pathogenesis of choroidal neovascularization. Arch Ophthalmol\u2008121:1283\u20131288, 2003","DOI":"10.1001\/archopht.121.9.1283"},{"key":"2022031215231199600_R41","doi-asserted-by":"crossref","unstructured":"Holekamp NM, Bouck N, Volpert O: Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration. Am J Ophthalmol\u2008134:220\u2013227, 2002","DOI":"10.1016\/S0002-9394(02)01549-0"},{"key":"2022031215231199600_R42","doi-asserted-by":"crossref","unstructured":"Ito Y, Aten J, Bende RJ, Oemar BS, Rabelink TJ, Weening JJ, Goldschmeding R: Expression of connective tissue growth factor in human renal fibrosis. Kidney Int\u200853:853\u2013861, 1998","DOI":"10.1111\/j.1523-1755.1998.00820.x"},{"key":"2022031215231199600_R43","doi-asserted-by":"crossref","unstructured":"Meyer P, Wunderlich K, Kain HL, Prunte C, Flammer J: Human connective tissue growth factor mRNA expression of epiretinal and subretinal fibrovascular membranes: a report of three cases. Ophthalmologica\u2008216:284\u2013291, 2002","DOI":"10.1159\/000063843"},{"key":"2022031215231199600_R44","doi-asserted-by":"crossref","unstructured":"Boes M, Dake BL, Booth BA, Erondu NE, Oh Y, Hwa V, Rosenfeld R, Bar RS: Connective tissue growth factor (IGFBP-rP2) expression and regulation in cultured bovine endothelial cells. Endocrinology\u2008140:1575\u20131580, 1999","DOI":"10.1210\/endo.140.4.6633"},{"key":"2022031215231199600_R45","unstructured":"Bochaton-Piallat ML, Kapetanios AD, Donati G, Redard M, Gabbiani G, Pournaras CJ: TGF-beta1, TGF-beta receptor II and ED-A fibronectin expression in myofibroblasts of vitreoretinopathy. Invest Ophthalmol Vis Sci\u200841:2336\u20132342, 2000"},{"key":"2022031215231199600_R46","doi-asserted-by":"crossref","unstructured":"Twigg SM, Chen MM, Joly AH, Chakrapani SD, Tsubaki J, Kim HS, Oh Y, Rosenfeld RG: Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: a potential mechanism for expansion of extracellular matrix in diabetes mellitus. Endocrinology\u2008142:1760\u20131769, 2001","DOI":"10.1210\/endo.142.5.8141"},{"key":"2022031215231199600_R47","doi-asserted-by":"crossref","unstructured":"Schild C, Trueb B: Mechanical stress is required for high-level expression of connective tissue growth factor. Exp Cell Res\u2008274:83\u201391, 2002","DOI":"10.1006\/excr.2001.5458"},{"key":"2022031215231199600_R48","doi-asserted-by":"crossref","unstructured":"Kondo S, Kubota S, Shimo T, Nishida T, Yosimichi G, Eguchi T, Sugahara T, Takigawa M: Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases. Carcinogenesis\u200823:769\u2013776, 2002","DOI":"10.1093\/carcin\/23.5.769"},{"key":"2022031215231199600_R49","doi-asserted-by":"crossref","unstructured":"Paradis V, Perlemuter G, Bonvoust F, Dargere D, Parfait B, Vidaud M, Conti M, Huet S, Ba N, Buffet C, Bedossa P: High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis. Hepatology\u200834:738\u2013744, 2001","DOI":"10.1053\/jhep.2001.28055"}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/27\/3\/758\/648745\/zdc00304000758.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/27\/3\/758\/648745\/zdc00304000758.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T15:25:31Z","timestamp":1647098731000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/27\/3\/758\/23023\/Accumulation-of-NH2-Terminal-Fragment-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,1]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.27.3.758","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,1]]}}}