{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:09:28Z","timestamp":1787836168302,"version":"build-2784847793"},"reference-count":41,"publisher":"American Diabetes Association","issue":"3","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,3,1]]},"abstract":"<jats:p>OBJECTIVE\u2014The aim of this study was to evaluate whether low insulin sensitivity (Si) measured using a modified frequently sampled intravenous glucose tolerance test with minimal model analysis is associated with coronary artery disease (CAD) independent of other cardiovascular risk factors.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014We studied 1,482 women and men, age 40\u201369 years old, African American (28%), Hispanic (34%), or non-Hispanic white (38%), with normal (45%), impaired (23%), or diabetic (32%) glucose tolerance. CAD defined as confirmed past myocardial infarction, coronary artery bypass graft, coronary angioplasty, or presence of a major Q-wave was found in 91 participants.<\/jats:p>\n               <jats:p>RESULTS\u2014The odds ratio (OR) for CAD was greatest among individuals in the two lowest quintiles of Si (2.4, 95% CI 1.0\u20135.6 and 4.7, 2.1\u201310.7) compared with the highest Si quintile. After adjusting for demographic and cardiovascular risk factors, a decrement from the 75th to 25th percentile in Si was associated with a 56% increase in CAD (P = 0.028). Similar increments in fasting or 2-h insulin levels were associated with, respectively, only 15 (NS) and 3% (NS) increases in CAD. The association between Si and CAD was partially mediated by insulin, HDL cholesterol and triglyceride levels, hypertension, diabetes, and obesity, but not LDL cholesterol or cigarette smoking.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014Low Si is associated with CAD independently of and stronger than plasma insulin levels. Part of the association is accounted for by dyslipidemia, hypertension, diabetes, and obesity.<\/jats:p>","DOI":"10.2337\/diacare.27.3.781","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"781-787","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":105,"title":["Insulin Sensitivity, Insulinemia, and Coronary Artery Disease"],"prefix":"10.2337","volume":"27","author":[{"given":"Marian","family":"Rewers","sequence":"first","affiliation":[{"name":"Barbara Davis Center, University of Colorado HSC, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zaccaro","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"D\u2019Agostino","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Haffner","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Texas HS, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed F.","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe V.","family":"Selby","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bergman","sequence":"additional","affiliation":[{"name":"Kaiser Research Center, Northern California, Division of Research, Oakland, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Savage","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Insulin Resistance Atherosclerosis Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031215200703800_R1","doi-asserted-by":"crossref","unstructured":"Reaven GM: Role of insulin resistance in human disease. 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