{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T17:51:10Z","timestamp":1726422670650},"reference-count":23,"publisher":"American Diabetes Association","issue":"6","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,6,1]]},"abstract":"<jats:p>OBJECTIVE\u2014Three blood markers of inflammation (high-sensitivity C-reactive protein [hsCRP], interleukin [IL]-6, and fibrinogen) were compared with markers of atherosclerotic cardiovascular disease (CVD) (history of stroke or cardiac ischemia and measured toe-brachial index [TBI]) to determine whether inflammatory markers are associated with atherosclerosis in patients with type 2 diabetes.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014Of 103 patients with type 2 diabetes, 26 had CVD. TBI was plethysmographically determined in both great toes. Serum hsCRP was immunonephelometrically determined. Plasma IL-6 was measured by an enzyme immunoassay.<\/jats:p>\n               <jats:p>RESULTS\u2014Both ABI and TBI were lower in diabetic patients with CVD than in those without CVD (1.05 \u00b1 0.19 vs. 1.14 \u00b1 0.09, P &amp;lt; 0.05, and 0.75 \u00b1 0.20 vs. 0.95 \u00b1 0.21, P &amp;lt; 0.001, respectively). By linear regression, right TBI but not right ABI showed a significant negative correlation with serum hsCRP (r = \u22120.372, P &amp;lt; 0.01) and plasma fibrinogen (r = \u22120.224, P &amp;lt; 0.05). Serum hsCRP was also negatively correlated with lower TBI, but not lower ABI. We found no significant correlation between plasma IL-6 and ABI or TBI.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014TBI was strongly associated with CVD, serum hsCRP, and plasma fibrinogen. Of these inflammatory markers, serum hsCRP may be the most promising marker for vascular inflammation.<\/jats:p>","DOI":"10.2337\/diacare.27.6.1381","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"1381-1386","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":22,"title":["Results of Blood Inflammatory Markers Are Associated More Strongly With Toe-Brachial Index Than With Ankle-Brachial Index in Patients With Type 2 Diabetes"],"prefix":"10.2337","volume":"27","author":[{"given":"Yoshimasa","family":"Aso","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-ichi","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruo","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rika","family":"Matsutomo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadao","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohzo","family":"Takebayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Inukai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","reference":[{"key":"2022031215164903800_R1","doi-asserted-by":"crossref","unstructured":"McDermott MM: Ankle brachial index as a predictor of outcomes in peripheral arterial disease. 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