{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:36:21Z","timestamp":1783064181779,"version":"3.54.6"},"reference-count":25,"publisher":"American Diabetes Association","issue":"8","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,8,1]]},"abstract":"<jats:p>OBJECTIVE\u2014We screened the human aldose reductase (ALR) gene for DNA sequence variants in type 2 diabetic and nondiabetic subjects and investigated whether the previously reported and novel polymorphisms were associated with neurophysiologic deterioration and clinical peripheral neuropathy.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014The study population included 85 Finnish type 2 diabetic and 126 nondiabetic subjects. The genetic analyses were performed using the PCR, single-strand conformation polymorphism, restriction fragment-length polymorphism, and automated laser fluorescence scanning analyses. A detailed neurologic examination and neurophysiologic analyses were performed at the time of diagnosis and at the 10-year examination.<\/jats:p>\n               <jats:p>RESULTS\u2014The genetic screening identified four polymorphisms: C-106T, C-11G, A11370G, and C19739A. The C and Z-2 alleles of the C-106T polymorphism and the previously reported (CA)n repeat marker were more frequent in type 2 diabetic subjects than in nondiabetic subjects. At baseline, the diabetic subjects with the T allele of the C-106T polymorphism had lower sensory response amplitude values in the peroneal (P = 0.025), sural (P = 0.007), and radial (P = 0.057) nerves and, during follow-up, a greater decrease in the conduction velocity of the motor peroneal nerve than those with the C-106C genotype. No associations were found between the polymorphisms examined and clinical polyneuropathy.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014The C-106T polymorphism of the ALR gene may contribute to an early development of neurophysiologic deterioration in type 2 diabetic patients.<\/jats:p>","DOI":"10.2337\/diacare.27.8.2021","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"2021-2026","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":31,"title":["Aldose Reductase Gene Polymorphisms and Peripheral Nerve Function in Patients With Type 2 Diabetes"],"prefix":"10.2337","volume":"27","author":[{"given":"Katariina","family":"Sivenius","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Pihlajama\u0308ki","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Kuopio, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhani","family":"Partanen","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, University of Kuopio, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Niskanen","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Kuopio, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Laakso","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Kuopio, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Uusitupa","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031216062154400_R1","doi-asserted-by":"crossref","unstructured":"The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. 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