{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:04:13Z","timestamp":1772111053598,"version":"3.50.1"},"reference-count":19,"publisher":"American Diabetes Association","issue":"6","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"abstract":"<jats:p>OBJECTIVE\u2014To evaluate the effects over 2 years of a weight loss program combining several weight loss strategies on weight loss and diabetes control in overweight subjects with type 2 diabetes.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014A total of 59 overweight or obese individuals with type 2 diabetes were randomly assigned to either a combination therapy weight loss program for 2 years (C therapy) or a standard therapy weight loss program for 1 year followed by a combination therapy weight loss program in the 2nd year (S\/C therapy). C therapy combined the use of meal replacement products, repetitive intermittent low-calorie-diet weeks, and pharmacologic therapy with sibutramine. Outcome measures included changes in weight, glycemic control, plasma lipids, blood pressure, and body composition over 2 years.<\/jats:p>\n               <jats:p>RESULTS\u2014A total of 48 participants (23 in the C therapy group and 25 in the S\/C therapy group) completed 2 years of study. After 2 years, the C therapy group had weight loss of 4.6 \u00b1 1.2 kg (P &amp;lt; 0.001) and a decrease in HbA1c of 0.5 \u00b1 0.3% (P = 0.08) from baseline. At 2 years, the C therapy group had significant reductions in BMI, fat mass, lean body mass, and systolic blood pressure. The S\/C therapy group showed changes in weight and HbA1c in year 2 of the study that were similar to those demonstrated by the C therapy group in year 1.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014This combination weight loss program resulted in significant weight loss and improved diabetes control over a 2-year period in overweight subjects with type 2 diabetes.<\/jats:p>","DOI":"10.2337\/diacare.28.6.1311","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"1311-1315","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":50,"title":["Two-Year Outcome of a Combination of Weight Loss Therapies for Type 2 Diabetes"],"prefix":"10.2337","volume":"28","author":[{"given":"J. Bruce","family":"Redmon","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine, General Clinical Research Center, and the Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristell P.","family":"Reck","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine, General Clinical Research Center, and the Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan K.","family":"Raatz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine, General Clinical Research Center, and the Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce E.","family":"Swanson","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine, General Clinical Research Center, and the Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine A.","family":"Kwong","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine, General Clinical Research Center, and the Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Ji","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine, General Clinical Research Center, and the Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Thomas","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine, General Clinical Research Center, and the Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Bantle","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine, General Clinical Research Center, and the Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","reference":[{"key":"2022031218460831400_R1","doi-asserted-by":"crossref","unstructured":"Consensus Development Conference on Diet and Exercise in Non-Insulin-Dependent Diabetes Mellitus: National Institutes of Health. 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