{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:32:52Z","timestamp":1762003972510},"reference-count":0,"publisher":"American Diabetes Association","issue":"4","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,7,1]]},"abstract":"<jats:p>Urinary albumin excretion rate (radial immunodiffusion), glomerular filtration rate (GFR) (single-shot 51Cr-EDTA technique), and arterial blood pressure (BP) were measured in 12 juvenile-onset, insulin-dependent diabetic patients with persistent proteinuria (&amp;gt; 0.5 g\/day) due to diabetic nephropathy. Mean age of the patients was 30 yr. All patients had a diastolic blood pressure \u226595 mm Hg. Metoprolol, hydralazine, and furosemide or thiazide were used as antihypertensives. During the 12-mo treatment period, BP decreased from 151\/104 to 133\/85 mm Hg (P &amp;lt; 0.001), the urinary albumin excretion rate diminished from 1447 to 613 \u03bcg\/min (P &amp;lt; 0.005), and GFR declined from 96 to 89 ml\/min\/1.73 m2 (P &amp;lt; 0.01). A linear relationship between mean blood pressure and the logarithm of the albuminuria was found (r = 0.48, P &amp;lt; 0.01). Arterial hypertension is an early feature of diabetic nephropathy in young insulin-dependent patients. Early and aggressive treatment of that condition decreases albuminuria, probably due to reduced intraglomerular filtration pressure. Whether sustained reduction in arterial blood pressure to near-normal levels during several years also reduces the rate of decline in GFR in diabetic nephropathy remains to be established.<\/jats:p>","DOI":"10.2337\/diacare.4.4.459","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"459-463","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":34,"title":["Reduced Albuminuria During Early and Aggressive Antihypertensive Treatment of Insulin-dependent Diabetic Patients with Diabetic Nephropathy"],"prefix":"10.2337","volume":"4","author":[{"given":"Hans-Henrik","family":"Parving","sequence":"first","affiliation":[{"name":"Steno Memorial Hospital, Gentofte, and Department of Clinical Physiology and Department of Medicine C, Bispebjerg Hospital\u2008Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan R","family":"Andersen","sequence":"additional","affiliation":[{"name":"Steno Memorial Hospital, Gentofte, and Department of Clinical Physiology and Department of Medicine C, Bispebjerg Hospital\u2008Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla M","family":"Smidt","sequence":"additional","affiliation":[{"name":"Steno Memorial Hospital, Gentofte, and Department of Clinical Physiology and Department of Medicine C, Bispebjerg Hospital\u2008Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Friisberg","sequence":"additional","affiliation":[{"name":"Steno Memorial Hospital, Gentofte, and Department of Clinical Physiology and Department of Medicine C, Bispebjerg Hospital\u2008Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per Aa","family":"Svendsen","sequence":"additional","affiliation":[{"name":"Steno Memorial Hospital, Gentofte, and Department of Clinical Physiology and Department of Medicine C, Bispebjerg Hospital\u2008Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/4\/4\/459\/547421\/4-4-459.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/4\/4\/459\/547421\/4-4-459.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T20:05:22Z","timestamp":1647115522000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/4\/4\/459\/27241\/Reduced-Albuminuria-During-Early-and-Aggressive"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,7,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.4.4.459","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,7,1]]}}}