{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T05:25:35Z","timestamp":1700717135149},"reference-count":0,"publisher":"American Diabetes Association","issue":"3","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,5,1]]},"abstract":"<jats:p>A diabetic woman presented with diabetic ketoacidosis after demonstrating immediate-type hypersensitivity to heterologous insulin. She had had interrupted insulin therapy in the past. Insulin requirements during the course of treatment for the acidosis suggested marked resistance, with 50,000 U of insulin needed in the first 36 h. Anaphylaxis requiring intubation and emergency treatment developed after intravenous purified pork insulin was administered. Elevated titers of insulin-specific IgG (441.6 U\/L serum) demonstrated immunologic insulin resistance. Positive intradermal skin tests for beef and pork insulins and detection of insulin-specific IgE by RAST assay revealed concurrent immediate-type allergy. A review of the literature revealed the unique occurrence in this patient of simultaneous ketoacidosis, insulin allergy, anaphylaxis, and immunologic resistance. Interrupted insulin therapy in susceptible individuals remains a potential danger, even with the availability of purified insulin preparations.<\/jats:p>","DOI":"10.2337\/diacare.7.3.276","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"276-279","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":8,"title":["Anaphylaxis and Immunologic Insulin Resistance in a Diabetic Woman with Ketoacidosis"],"prefix":"10.2337","volume":"7","author":[{"given":"Jonathan M","family":"Ross","sequence":"first","affiliation":[{"name":"Department of Medicine, State University of New York, Downstate Medical Center\u2008Brooklyn, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandakolathur R","family":"Murali","sequence":"additional","affiliation":[{"name":"Department of Medicine, State University of New York, Downstate Medical Center\u2008Brooklyn, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresita C","family":"DeLara","sequence":"additional","affiliation":[{"name":"Department of Medicine, State University of New York, Downstate Medical Center\u2008Brooklyn, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G","family":"Cheron","sequence":"additional","affiliation":[{"name":"Department of Medicine, State University of New York, Downstate Medical Center\u2008Brooklyn, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/7\/3\/276\/496627\/7-3-276.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/7\/3\/276\/496627\/7-3-276.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:01:51Z","timestamp":1647129711000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/7\/3\/276\/32769\/Anaphylaxis-and-Immunologic-Insulin-Resistance-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,5,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.7.3.276","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,5,1]]}}}