{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:14:36Z","timestamp":1790471676833,"version":"4.1.0"},"reference-count":0,"publisher":"American Diabetes Association","issue":"5","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,9,1]]},"abstract":"<jats:p>Four cases (belonging to two different families) of Wolfram's syndrome (WS), a rare congenital disease characterized in its complete form by insulin-dependent diabetes mellitus, optic atrophy, diabetes insipidus, deafness, and dilation of the urinary tracts are presented, and a review of the literature is included. Three of four patients are characterized by HLA-DR2 haplotype, which is rare in IDDM. The neurodegenerative nature of some symptoms and the possible pathogenesis of diabetes mellitus connected with it are discussed.<\/jats:p>","DOI":"10.2337\/diacare.9.5.521","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T22:51:27Z","timestamp":1173135087000},"page":"521-528","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":35,"title":["Wolfram's Syndrome: A Clinical, Diagnostic, and Interpretative Contribution"],"prefix":"10.2337","volume":"9","author":[{"given":"C","family":"Blasi","sequence":"first","affiliation":[{"name":"Cattedra di Endocrinologia 1, Istituto di Clinica delle malattie nervose e mentali 2, Clinica Oculistica 1, Clinica Otorinolaringoiatrica 5, Universita' degli studi di Roma \u201cLa Sapienza,\u201d\u2008Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Pierelli","sequence":"additional","affiliation":[{"name":"Cattedra di Endocrinologia 1, Istituto di Clinica delle malattie nervose e mentali 2, Clinica Oculistica 1, Clinica Otorinolaringoiatrica 5, Universita' degli studi di Roma \u201cLa Sapienza,\u201d\u2008Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Rispoli","sequence":"additional","affiliation":[{"name":"Cattedra di Endocrinologia 1, Istituto di Clinica delle malattie nervose e mentali 2, Clinica Oculistica 1, Clinica Otorinolaringoiatrica 5, Universita' degli studi di Roma \u201cLa Sapienza,\u201d\u2008Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Saponara","sequence":"additional","affiliation":[{"name":"Cattedra di Endocrinologia 1, Istituto di Clinica delle malattie nervose e mentali 2, Clinica Oculistica 1, Clinica Otorinolaringoiatrica 5, Universita' degli studi di Roma \u201cLa Sapienza,\u201d\u2008Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Vingolo","sequence":"additional","affiliation":[{"name":"Cattedra di Endocrinologia 1, Istituto di Clinica delle malattie nervose e mentali 2, Clinica Oculistica 1, Clinica Otorinolaringoiatrica 5, Universita' degli studi di Roma \u201cLa Sapienza,\u201d\u2008Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Andreani","sequence":"additional","affiliation":[{"name":"Cattedra di Endocrinologia 1, Istituto di Clinica delle malattie nervose e mentali 2, Clinica Oculistica 1, Clinica Otorinolaringoiatrica 5, Universita' degli studi di Roma \u201cLa Sapienza,\u201d\u2008Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/9\/5\/521\/550532\/9-5-521.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/9\/5\/521\/550532\/9-5-521.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T23:11:44Z","timestamp":1647126704000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/9\/5\/521\/31530\/Wolfram-s-Syndrome-A-Clinical-Diagnostic-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,9,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1986,9,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diacare.9.5.521","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,9,1]]}}}