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Baseline hsCRP, LDL-C, and Lp(a) were dichotomized according to guideline-recommended target levels. Patients were followed for incident atherosclerotic cardiovascular disease (ASCVD), total CVD (ASCVD plus heart failure), death, or study end. Competing risk models adjusted for important covariates were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>There were 29,658 patients with type 2 diabetes who were followed for a median of 15 years. Those with all three biomarkers above target had significantly increased risks compared with those with all at target: fatal and nonfatal ASCVD (adjusted hazard ratio 1.59; 95% CI 1.24, 2.03) and total CVD (adjusted hazard ratio 1.44; 95% CI 1.13, 1.83). Cardiovascular risk increased progressively as fewer biomarkers achieved target levels (all Ptrend &amp;lt; 0.001), with stronger associations in patients with shorter diabetes duration (&amp;lt;2 years vs. \u22652 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Elevated hsCRP, LDL-C, and Lp(a) showed dose-dependent associations with cardiovascular risk in patients with type 2 diabetes, supporting their control in cardiovascular risk prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/doc26-0039","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:06:55Z","timestamp":1784297215000},"page":"671-681","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Joint Control of Inflammation, Cholesterol, and Lipoprotein(a) With Incident Cardiovascular Events in People With Type 2 Diabetes"],"prefix":"10.2337","volume":"1","author":[{"given":"Yi-Hsuan","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Medical Education, Taipei Veterans General Hospital 1 , Taipei, Taiwan"},{"name":"Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University 2 , New Orleans, LA"},{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University 3 , Taipei, Taiwan"},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University 4 , Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University 2 , New Orleans, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0957-9309","authenticated-orcid":false,"given":"Yoriko","family":"Heianza","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University 2 , New Orleans, LA"},{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health 5 , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-8351","authenticated-orcid":false,"given":"Kuo-Liong","family":"Chien","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University 3 , Taipei, Taiwan"},{"name":"Department of Internal Medicine, National Taiwan University Hospital and College of Medicine 6 , Taipei, Taiwan"},{"name":"Population Health Research Center, National Taiwan University 7 , Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8041-7791","authenticated-orcid":false,"given":"Lu","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University 2 , New Orleans, LA"},{"name":"Department of Nutrition, Harvard T.H. 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