{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:55:44Z","timestamp":1792788944146,"version":"4.5.0"},"reference-count":41,"publisher":"American Diabetes Association","issue":"5","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"name":"Health Services and Outcomes Research in Aging Population T32","award":["T32AG066576"],"award-info":[{"award-number":["T32AG066576"]}]},{"name":"National Institute of Nursing Research of the National Institutes of Health","award":["R56NR020466, R01NR020197"],"award-info":[{"award-number":["R56NR020466, R01NR020197"]}],"id":[{"id":"https:\/\/ror.org\/01y3zfr79","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Treatment with a glucagon-like peptide 1 receptor agonist (GLP-1RA) is an effective pharmacotherapy for obesity and diabetes care, but physical activity patterns among adults taking this class of medication have not been well described. Thus, the objective of this study was to characterize physical activity patterns in U.S. adults taking a GLP-1RA and identify sociodemographic and clinical factors associated with low activity levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>We conducted a cross-sectional study using data from the National Institutes of Health All of Us Research Program (2018\u20132022). Adults aged \u226518 years who were taking a GLP-1RA and had valid fitness tracker data were included. Outcomes of interest were daily total and moderate-to-vigorous physical activity time, step count, and sedentary time. Covariates included age, sex, race, education, income, diabetes status, and GLP-1RA type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 298 participants (mean \u00b1 SD age 52.6 \u00b1 12.6 years), daily total physical activity time was 204 \u00b1 76 min, including 24 \u00b1 21 min of moderate-to-vigorous activity. More than half of participants (57.7%) did not meet the recommended \u2265150 min\/week of moderate-to-vigorous activity. Mean step count\/day \u00b1 SD was 5,944 \u00b1 2,699 steps and sedentary time\/day was 947 \u00b1 189 min. Injectable semaglutide was associated with a greater amount of physical activity, whereas older age, female sex, lower income, and diabetes were associated with less activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The majority of adults taking a GLP-1RA did not meet recommended levels of physical activity. Findings highlight the need for targeted interventions to promote physical activity among adults taking a GLP-1RA and suggest a beneficial relationship between semaglutide and a more active lifestyle, which will need to be explored in future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/doc26-0062","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T16:01:11Z","timestamp":1785945671000},"page":"823-830","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Physical Activity Patterns in Adults Taking Glucagon-Like Peptide 1 Receptor Agonists: An\n                    <i>All of Us<\/i>\n                    Cross-sectional Study"],"prefix":"10.2337","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2785-2947","authenticated-orcid":false,"given":"Kacey","family":"Chae","sequence":"first","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine 1 , Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda R.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health 2 , Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Biostatistics, Epidemiology and Data Management Core, Johns Hopkins University School of Medicine 3 , Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotsna","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine 1 , Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvi","family":"Rajagopal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine 1 , Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-8973","authenticated-orcid":false,"given":"Ariana M.","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine 1 , Baltimore, MD"},{"name":"Johns Hopkins School of Nursing 4 , Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"2026101610015489600_B1","doi-asserted-by":"crossref","first-page":"e076410","DOI":"10.1136\/bmj-2023-076410","article-title":"Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis","volume":"384","author":"Yao","year":"2024","journal-title":"BMJ"},{"key":"2026101610015489600_B2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0140-6736(21)01324-6","article-title":"Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial","volume":"398","author":"Rosenstock","year":"2021","journal-title":"Lancet"},{"key":"2026101610015489600_B3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1056\/NEJMoa2206038","article-title":"Tirzepatide once weekly for the treatment of obesity","volume":"387","author":"Jastreboff","year":"2022","journal-title":"N Engl J Med"},{"key":"2026101610015489600_B4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41366-024-01473-y","article-title":"What is the pipeline for future medications for obesity?","volume":"49","author":"Melson","year":"2025","journal-title":"Int J Obes (Lond)"},{"key":"2026101610015489600_B5","doi-asserted-by":"crossref","first-page":"S181","DOI":"10.2337\/dc25-S009","article-title":"9. 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