{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T01:26:50Z","timestamp":1772242010736,"version":"3.50.1"},"reference-count":38,"publisher":"American Diabetes Association","issue":"7","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":3721,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Previous studies have found that high insulin sensitivity predicts weight gain; this association has not been confirmed. Our aim was to systematically analyze metabolic predictors of spontaneous weight changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>In 561 women and 467 men from the Relationship Between Insulin Sensitivity and Cardiovascular Disease (RISC) cohort (mean age 44 years, BMI range 19\u201344 kg\/m2, 9% impaired glucose tolerance) followed up for 3 years, we measured insulin sensitivity (by a euglycemic clamp) and \u03b2-cell function (by modeling of the C-peptide response to oral glucose and by acute insulin response to intravenous glucose).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Insulin sensitivity was similar in weight gainers (top 20% of the distribution of BMI changes), weight losers (bottom 20%), and weight stable subjects across quartiles of baseline BMI. By multiple logistic or linear regression analyses controlling for center, age, sex, and baseline BMI, neither insulin sensitivity nor any \u03b2-cell function parameter showed an independent association with weight gain; this was true in normal glucose tolerance, impaired glucose tolerance, and whether subjects progressed to dysglycemia or not. Baseline BMI was significantly higher in gainers (26.1 \u00b1 4.1 kg\/m2) and losers (26.6 \u00b1 3.7 kg\/m2) than in weight stable subjects (24.8 \u00b1 3.8 kg\/m2, P &amp;lt; 0.0001 for both gainers and losers). Baseline waist circumference (or equivalently, BMI or weight) was a positive, independent predictor of both weight gain and weight loss (odds ratio 1.48 [95% CI 1.12\u20131.97]) in men and (1.67 [1.28\u20132.12]) in women. In men only, better insulin sensitivity was an additional independent predictor of weight loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Neither insulin sensitivity nor insulin secretion predicts spontaneous weight gain. Individuals who have attained a higher weight are prone to either gaining or losing weight regardless of their glucose tolerance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/db11-0217","type":"journal-article","created":{"date-parts":[[2011,5,27]],"date-time":"2011-05-27T01:29:23Z","timestamp":1306459763000},"page":"1938-1945","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":19,"title":["Body Weight, Not Insulin Sensitivity or Secretion, May Predict Spontaneous Weight Changes in Nondiabetic and Prediabetic Subjects"],"prefix":"10.2337","volume":"60","author":[{"given":"Eleni","family":"Rebelos","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Pisa, Italy"}]},{"given":"Elza","family":"Muscelli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pisa, Italy"}]},{"given":"Andrea","family":"Natali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pisa, Italy"}]},{"given":"Beverley","family":"Balkau","sequence":"additional","affiliation":[{"name":"INSERM Unit 1018, Villejuif, France"}]},{"given":"Geltrude","family":"Mingrone","sequence":"additional","affiliation":[{"name":"Catholic University School of Medicine, Rome, Italy"}]},{"given":"Piermarco","family":"Piatti","sequence":"additional","affiliation":[{"name":"Diabetology, Endocrinology, and Metabolic Disease Unit, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy"}]},{"given":"Thomas","family":"Konrad","sequence":"additional","affiliation":[{"name":"Clinic of Pediatrics I, Johan Wolfgang Goethe Universitat am Main, Frankfurt, Germany"}]},{"given":"Andrea","family":"Mari","sequence":"additional","affiliation":[{"name":"CNR Institute of Biomedical Engineering, Padua, Italy"}]},{"given":"Ele","family":"Ferrannini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pisa, Italy"}]},{"name":"on behalf of the RISC Study Investigators","sequence":"additional","affiliation":[]}],"member":"1167","published-online":{"date-parts":[[2011,6,20]]},"reference":[{"key":"2022031209424260300_B1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1172\/JCI115274","article-title":"Insulin resistance associated with lower rates of weight gain in Pima Indians","volume":"88","author":"Swinburn","year":"1991","journal-title":"J Clin Invest"},{"key":"2022031209424260300_B2","first-page":"85","article-title":"Predictors of weight change in a bi-ethnic population. 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