{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:03:05Z","timestamp":1761562985752},"reference-count":0,"publisher":"Medical Journals Sweden AB","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>A randomized, double\/blind, placebo\/controlled, international multicenter trial was conducted, using 1.5 MIU subcutaneous interferon alpha\/2a 3 times a week for 4 weeks in 170 patients (interferon, n = 125 or placebo, n = 45) with condylomata acuminata who had failed to respond to standard therapies. There was no difference in efficacy between the interferon alpha\/2a and placebo treatment groups at 3 months after commencement of therapy. Although the recurrence rate at the end of 9 months' follow\/up appeared lower in the interferon alpha\/2a group than in the placebo group (9% versus 22%), this difference was not statistically significant. Most of the adverse events reported were typical interferon\/associated mild to moderate flu\/like symptoms. It is concluded that subcutaneous interferon alpha\/2a, administered according to the current dosage and treatment schedule, is not effective as monotherapy in the treatment of refractory condylomata acuminata.<\/jats:p>","DOI":"10.2340\/0001555573223226","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T10:01:45Z","timestamp":1688637705000},"page":"223-226","source":"Crossref","is-referenced-by-count":19,"title":["Recurrent condylomata acuminata treated with recombinant interferon alpha\/2a. A multicenter double\/blind placebo\/controlled clinical trial. Condylomata International Collaborative Study Group."],"prefix":"10.2340","volume":"73","author":[{"given":"No authors","family":"Listed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[1993,6,1]]},"container-title":["Acta Dermato-Venereologica"],"original-title":[],"link":[{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/16516\/20382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/16516\/20382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T07:47:08Z","timestamp":1700120828000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/view\/16516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1993,6,1]]}},"URL":"https:\/\/doi.org\/10.2340\/0001555573223226","relation":{},"ISSN":["1651-2057","0001-5555"],"issn-type":[{"value":"1651-2057","type":"electronic"},{"value":"0001-5555","type":"print"}],"subject":[],"published":{"date-parts":[[1993,6,1]]}}}