{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:18:24Z","timestamp":1700180304099},"reference-count":0,"publisher":"Medical Journals Sweden AB","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>The area of UV erythema produced by a small beam head was found to increase with increasing doses. The aim was to investigate whether measurement of the area could be a more useful indicator of UV\/induced damage than classic visual grading. Topical pretreatment with all\/trans retinoic acid (tretinoin) and betamethasone valerate was used to test the applicability of the method in pharmacological studies. We used a round outlet head (5 mm2) connected by optical fibre to a monochromatic irradiator, and doses ranging from 0.05 to 0.2 Joule of 300 mm UV light were applied to the skin of 6 healthy subjects. Erythemal area was calculated by the measurement of two diameters, and intensity was graded visually (0\/6 scale). The area of the erythema correlated with the increase in intensity up to score 6. Area measurement was less subject to intra\/investigators' variability than the intensity score. By multiplying intensity by area, a good indicator of UV\/induced reactivity was obtained. Pretreatment with betamethasone valerate decreased the area of erythema, as did tretinoin 12 h after irradiation. Thus, area measurement of erythema is a useful adjunct to visual grading of UV\/induced skin reactions.<\/jats:p>","DOI":"10.2340\/0001555573273275","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T10:04:37Z","timestamp":1688637877000},"page":"273-275","source":"Crossref","is-referenced-by-count":0,"title":["Intensity and area increase of UVB\/induced erythema: two variables used for studies of the influence of topically applied drugs."],"prefix":"10.2340","volume":"73","author":[{"given":"L","family":"Juhlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Shroot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[1993,8,1]]},"container-title":["Acta Dermato-Venereologica"],"original-title":[],"link":[{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/16529\/20395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/16529\/20395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T07:47:12Z","timestamp":1700120832000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/view\/16529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1993,8,1]]}},"URL":"https:\/\/doi.org\/10.2340\/0001555573273275","relation":{},"ISSN":["1651-2057","0001-5555"],"issn-type":[{"value":"1651-2057","type":"electronic"},{"value":"0001-5555","type":"print"}],"subject":[],"published":{"date-parts":[[1993,8,1]]}}}