{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:15:12Z","timestamp":1791306912763,"version":"4.3.1"},"reference-count":0,"publisher":"Medical Journals Sweden AB","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>Significant cutaneous vascular IgA deposits are common in Henoch-Sch\u00f6nlein purpura but not in other vasculitides. The specificity for IgA vascular deposits for Henoch-Sch\u00f6nlein purpura is not well defined. To examine the specificity of IgA vascular deposits for this disease, we compared clinicopathologic features of 92 cases with IgA vascular deposits and a direct immunofluorescence impression of vasculitis with 90 similar cases without IgA deposits. Henoch-Sch\u00f6nlein purpura was diagnosed in 24% of cases with vascular IgA deposits on direct immunofluorescence examination. IgA deposits were frequent in erythema nodosum and venous stasis-related problems and in cryoglobulinemia, coagulopathic vasculopathies, and livedoid vasculitis. Of our cases, 78% exhibited vascular fluorescence with multiple conjugates. No histologic or immunofluorescence pattern alone was specific. The diagnostic specificity for Henoch-Sch\u00f6nlein purpura is improved if gastrointestinal involvement, upper respiratory infection, or age &lt; 20 years is present. We propose diagnostic criteria for Henoch-Sch\u00f6nlein purpura incorporating clinical findings yielding sensitivity and specificity &gt; 90%.<\/jats:p>","DOI":"10.2340\/0001555575125129","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T08:42:40Z","timestamp":1687164160000},"page":"125-129","source":"Crossref","is-referenced-by-count":68,"title":["Henoch-Sch\u00f6nlein purpura: clinicopathologic correlation of cutaneous vascular IgA deposits and the relationship to leukocytoclastic vasculitis."],"prefix":"10.2340","volume":"75","author":[{"given":"S D","family":"Helander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F R","family":"De Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L E","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[1995,3,1]]},"container-title":["Acta Dermato-Venereologica"],"original-title":[],"link":[{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/15167\/18922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/15167\/18922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T07:43:49Z","timestamp":1700120629000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/view\/15167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1995,3,1]]}},"URL":"https:\/\/doi.org\/10.2340\/0001555575125129","relation":{},"ISSN":["1651-2057","0001-5555"],"issn-type":[{"value":"1651-2057","type":"electronic"},{"value":"0001-5555","type":"print"}],"subject":[],"published":{"date-parts":[[1995,3,1]]}}}