{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:13:20Z","timestamp":1789665200049,"version":"4.0.1"},"reference-count":21,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ActaO"],"abstract":"<jats:p>Early implant migration is an indicator of the long-term survival\/failure of implants. CT-based radio-stereometric analysis (CT-RSA) is a precise method for measuring and visualizing implant migration in vivo using image processing of CT scans. This makes the method widely applicable to orthopedic researcher.Since its development in the early 2000s, CT-RSA has benefited from breakthroughs in CT and computing technology. These advancements have allowed for the acquisition of images with higher resolution at a much lower radiation dose. As a result, the measurement precision of CT-RSA is now comparable to that of the current gold standard technology while still compatible with most ethical considerations regarding radiation exposure.In this review we present bests practices for the successful execution of CT-RSA research projects. These practices are based on experience from projects on the hip, knee, shoulder, lower back, cervical spine, foot, pelvis, and wrist.\n\u00a0<\/jats:p>","DOI":"10.2340\/17453674.2023.15337","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T10:06:30Z","timestamp":1690365990000},"page":"373-378","source":"Crossref","is-referenced-by-count":32,"title":["Computed tomography-based radiostereometric analysis in orthopedic research: practical guidelines"],"prefix":"10.2340","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5825-1692","authenticated-orcid":false,"given":"Olof H","family":"Sandberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4782-7999","authenticated-orcid":false,"given":"Johan","family":"K\u00e4rrholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Olivecrona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-2055","authenticated-orcid":false,"given":"Stephan M","family":"R\u00f6hrl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof G","family":"Sk\u00f6ldenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Brod\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"35429","doi-asserted-by":"crossref","unstructured":"Hasan S, Marang-van de Mheen P J, Kaptein B L, Nelissen R G H H, Pijls B G. RSA-tested TKA implants on average have lower mean 10-year revision rates than non-RSA-tested designs. Clin Orthop Relat Res 2020; 478(6): 1232-41. doi: 10.1097\/CORR.0000000000001209.","DOI":"10.1097\/CORR.0000000000001209"},{"key":"35430","doi-asserted-by":"crossref","unstructured":"Nelissen R G H H, Pijls B G, K\u00e4rrholm J, Malchau H, Nieuwenhuijse M J, Valstar E R. RSA and registries: the quest for phased introduction of new implants. J Bone Joint Surg Am 2011; 93(Suppl. 3): 62-5. doi: 10.2106\/JBJS.K.00907.","DOI":"10.2106\/JBJS.K.00907"},{"key":"35431","doi-asserted-by":"crossref","unstructured":"Wretenberg P, Carlsson S, Tholen S, Olivecrona H. Implant movement analysis (IMA), a new CT based technique for diagnosis of aseptic loosening of total knee arthroplasty. Orthop Res Online J 2021; 8(3): 868-72. doi: 10.31031\/OPROJ.2021.08.000690.","DOI":"10.31031\/OPROJ.2021.08.000690"},{"key":"35432","doi-asserted-by":"crossref","unstructured":"Brod\u00e9n C, Reilly P, Khanna M, Popat R, Olivecrona H, Griffiths D, et al. CT-based micromotion analysis method can assess early implant migration and development of radiolucent lines in cemented glenoid components: a clinical feasibility study. Acta Orthop 2022; 93: 277-83. doi: 10.2340\/17453674.2022.1976.","DOI":"10.2340\/17453674.2022.1976"},{"key":"35433","doi-asserted-by":"crossref","unstructured":"Berger R, Fletcher F, Donaldson T, Wasielewski R, Peterson M, Rubash H. Dynamic test to diagnose loose uncemented femoral total hip components. 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The AGREE Reporting Checklist: a tool to improve reporting of clinical practice guidelines. BMJ 2016;3 52: i1152. doi: 10.1136\/bmj.i1152.","DOI":"10.1136\/bmj.i1152"},{"key":"35437","doi-asserted-by":"crossref","unstructured":"Valstar E R, Gill R, Ryd L, Flivik G, B\u00f6rlin N, K\u00e4rrholm J. Guidelines for standardization of radiostereometry (RSA) of implants. Acta Orthop 2005; 76(4): 563-72. doi: 10.1080\/17453670510041574.","DOI":"10.1080\/17453670510041574"},{"key":"35438","unstructured":"ISO SIoIS. ISO 16087:2013 Implants for surgery: Roentegen stereophotogrammetric analysis for the assessment of migration of orthopaedic implants. Geneva: ISO."},{"key":"35439","unstructured":"European Commission. Radiation Protection 99. Guidance on medical exposures in medical and biomedical research; 1998. Available from: https:\/\/energy.ec.europa.eu\/system\/files\/2014-11\/099_en_1.pdf."},{"key":"35440","doi-asserted-by":"crossref","unstructured":"Geijer M, Rundgren G, Weber L, Flivik G. Effective dose in low-dose CT compared with radiography for templating of total hip arthroplasty. Acta Radiol 2017; 58(10): 1276-82. doi: 10.1177\/0284185117693462.","DOI":"10.1177\/0284185117693462"},{"key":"35441","doi-asserted-by":"crossref","unstructured":"Valstar E R, De Jong F W, Vrooman H A, Rozing P M, Reiber J H C. Model-based Roentgen stereophotogrammetry of orthopaedic implants. J Biomech 2001; 34(6): 715-22. doi: 10.1016\/s0021-9290(01)00028-8.","DOI":"10.1016\/S0021-9290(01)00028-8"},{"key":"35442","doi-asserted-by":"crossref","unstructured":"Blom I F, Koster L A, Brinke B Ten, Mathijssen N M C. Effective radiation dose in radiostereometric analysis of the hip. Acta Orthop 2020; 91(4): 390-5. doi: 10.1080\/17453674.2020.1767443.","DOI":"10.1080\/17453674.2020.1767443"},{"key":"35443","doi-asserted-by":"crossref","unstructured":"Brod\u00e9n C, Sandberg O, Olivecrona H, Emery R, Sk\u00f6ldenberg O. 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J Bone Joint Surg Br 1994;76(6): 912-17.","DOI":"10.1302\/0301-620X.76B6.7983118"},{"key":"35446","doi-asserted-by":"crossref","unstructured":"Ryd L, Albrektsson B E, Carlsson L, Dansgard F, Herberts P, Lindstrand A, et al. Roentgen stereophotogrammetric analysis as a predictor of mechanical loosening of knee prostheses. J Bone Joint Surg Br 1995; 77(3): 377-83.","DOI":"10.1302\/0301-620X.77B3.7744919"},{"key":"35447","doi-asserted-by":"crossref","unstructured":"Gudnason A, Adalberth G, Nilsson K-G, Hailer N P. Tibial component rotation around the transverse axis measured by radiostereometry predicts aseptic loosening better than maximal total point motion. Acta Orthop 2017; 88(3): 282-7. doi: 10.1080\/17453674.2017.1297001.","DOI":"10.1080\/17453674.2017.1297001"},{"key":"35448","doi-asserted-by":"crossref","unstructured":"Dyreborg K, Andersen M R, Winther N, Solgaard S, Flivik G, Petersen M M. Migration of the uncemented Echo Bi-Metric and Bi-Metric THA stems: a randomized controlled RSA study involving 62 patients with 24-month follow-up. Acta Orthop 2020; 91(6): 693-8. doi: 10.1080\/17453674.2020.1802682.","DOI":"10.1080\/17453674.2020.1802682"},{"key":"35449","doi-asserted-by":"crossref","unstructured":"Eriksson T, Maguire G Q, Noz M E, Zeleznik M P, Olivecrona H, Shalabi A, et al. Are low-dose CT scans a satisfactory substitute for stereoradiographs for migration studies? A preclinical test of low-dose CT scanning protocols and their application in a pilot patient. 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